# Development of a Janus tissue adhesive hemostatic patch based on hydrophobically-modified Alaska pollock gelatin

https://mdr.nims.go.jp/datasets/e5887220-8209-4d8e-8e9a-2fdb7e9f6592

## File

- [BIOADV-D-24-00573_R1.pdf](https://mdr.nims.go.jp/filesets/bd670d8f-14ee-4f2f-be04-5f390eb4da54/download) ([Detail](https://mdr.nims.go.jp/filesets/bd670d8f-14ee-4f2f-be04-5f390eb4da54.md))

## Id

e5887220-8209-4d8e-8e9a-2fdb7e9f6592

## Local identifier



## Visibility

open_to_public

## State

published

## Created at

2024-09-09T06:59:44.647117Z

## Updated at

2024-09-09T08:25:58.479496Z

## Published at

2026-09-02T23:27:27.641362Z

## Doi

https://doi.org/10.48505/nims.4731

## First published url

https://doi.org/10.1016/j.bioadv.2024.214028

## Date published

2024-09-04

## Recorded date published

2025-1

## Resource type

journal_article

## Manuscript type

accepted_manuscript

## Collection



## Title

- title: Development of a Janus tissue adhesive hemostatic patch based on hydrophobically-modified
    Alaska pollock gelatin
  title_type: original
  lang: en

## Description

- description: "Uncontrollable hemorrhage resulting from trauma and surgical operation
    leads to high\r\n mortality rates. Although several patch-type hemostatic materials
    have been used in\r\n the clinic, achieving sufficient tissue adhesion and managing
    and preventing unwanted\r\n tissue adhesion have been challenging. In this study,
    we designed a Janus tissue\r\n adhesive hemostatic patch consisting of organic
    Alaska pollock gelatin (Org-ApGltn) as\r\n a support layer and decanoyl group-modified
    ApGltn (C10-ApGltn) with pentaerythritol\r\n poly(ethylene glycol) ether tetrasuccinimidyl
    glutarate (4S-PEG) as an adhesive layer,\r\n named C10-ApGltn patch. The C10-ApGltn
    patch adhered onto the surface of blood\r\n vessels by activated 4S-PEG and hydrophobic
    groups in C10-ApGltn through covalent\r\n bond formation and physical interaction.
    The burst strength of the C10-ApGltn patch\r\n was optimized in terms of the degree
    of substitution, the molecular weight of 4S-PEG,\r\n the concentration of C10-ApGltn,
    and the NHS/NH2 ratio. The optimized C10-ApGltn\r\n patch showed significantly
    higher burst strength with commercially available fibrin\r\n sealant patch (TachoSil®).
    It also showed enzymatic degradability in a buffer solution\r\n with collagenase.
    In a rat model of liver hemorrhage, the C10-ApGltn patch acted as a\r\n sealant
    on the hemorrhage site and exhibited hemostatic efficacy comparable to that of\r\n
    TachoSil®."
  description_type: abstract
  lang: und

## Creator

- name: Shima Ito
  role: author
  orcid: https://orcid.org/0000-0002-3233-617X
- name: Shiharu Watanabe
  role: author
- name: Hiyori Komatsu
  role: author
  orcid: https://orcid.org/0000-0002-2525-1362
- name: Kazuhiro Nagasaka
  role: author
- name: Debabrata Palai
  role: author
  orcid: https://orcid.org/0000-0003-1192-6143
- name: Naoki Maki
  role: author
- name: Tetsuo Tai
  role: author
- name: Kazuto Sugai
  role: author
- name: Tomoyuki Kawamura
  role: author
- name: Yukio Sato
  role: author
- name: Tetsushi Taguchi
  role: author
  orcid: https://orcid.org/0000-0003-2541-2530

## Contact agent



## Publisher

organization: Elsevier BV

## Managing organization



## Keyword

- subject: hemorrhage
  schema: not_defined
- subject: hemostatic patch
  schema: not_defined
- subject: Janus structure
  schema: not_defined
- subject: Alaska pollock gelatin
  schema: not_defined

## Rights

- identifier: https://creativecommons.org/licenses/by-nc-nd/4.0/

## Other identifier(s)



## Data origin

- data_origin_type: other

## Embargo

start_date: 2024-09-03
end_date: 2026-09-03

## Journal

- title: Biomaterials Advances
  issn: '27729508'
  volume: '166'
  article_number: '214028'

## Conference



## Related item



## Funding

- funder_name: Japan Society for the Promotion of Science

## Instrument



## Instrument operator



## Instrument managing organization



## Measurement method



## Specimen



## Chemical composition



## Structure for specimen



## Structural feature for specimen



## Specific property for specimen



## Process for specimen treatment



## Computational method



## Energy level/transition state



## Software



## Custom property



## Fileset

- id: bd670d8f-14ee-4f2f-be04-5f390eb4da54
  filename: BIOADV-D-24-00573_R1.pdf
  content_type: application/pdf
  size: 2134942
  md5: 7f02bfefc232a387a5aeb05976b1fffb

## Thumbnail

fileset_id: bd670d8f-14ee-4f2f-be04-5f390eb4da54
filename: BIOADV-D-24-00573_R1.pdf