# Advances in bioinspired polymer hydrogel systems with biomedical functionalities

https://mdr.nims.go.jp/datasets/e2213a44-4c98-45c5-84cf-464bbaea8e3d

## File

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## Id

e2213a44-4c98-45c5-84cf-464bbaea8e3d

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## Visibility

open_to_public

## State

published

## Created at

2025-03-25T05:19:53.483608Z

## Updated at

2025-07-16T07:17:04.419242Z

## Published at

2025-04-02T09:09:47.101246Z

## Doi

https://doi.org/10.48505/nims.5381

## First published url

https://doi.org/10.1080/14686996.2025.2469490

## Date published

2025-12-31

## Recorded date published

2025-12-31

## Resource type

journal_article

## Manuscript type

accepted_manuscript

## Collection



## Title

- title: Advances in bioinspired polymer hydrogel systems with biomedical functionalities
  title_type: original
  lang: en

## Description

- description: "The concepts of bioinspiration and biomimetics that seek to elucidate
    the\r\nmorphology and functions of living organisms and specific reactions within
    cells, and extraction\r\nof important elements from these concepts to design functional
    molecules and high-performance\r\nmaterials are becoming more and more widespread.
    This review summarizes the progress in\r\nresearch on hydrogels inspired by the
    stimuli-responsiveness of cell functions. For application\r\nto a self-regulated
    release system of insulin to regulate blood glucose levels, various polymer\r\nhydrogels
    have been designed using bioactive molecules such as enzymes and lectins to sense\r\nglucose
    concentrations. In addition, as a fully synthetic glucose-responsive hydrogel,
    a complex\r\nof a polymer having phenylboronic acid groups that form reversible
    bonds with sugars and a\r\nmultivalent hydroxyl group polymer has been researched.
    This reversible hydrogel system can\r\nbe further developed to act as an extracellular
    matrix in which cells can preferably reside. The\r\nproliferation and differentiation
    of encapsulated cells in hydrogels are controlled by reversible\r\nchanges in
    the hydrogel properties in response to sugar. Another advantage is that cells
    can be\r\nsafely retrieved by adding sugar to dissociate the hydrogel. These bioinspired
    polymer\r\nhydrogels can serve as important materials for the development of new
    medical technologies,\r\nsuch as the controlled release of bioactive molecules,
    regulated cell culture environmental\r\nmatrices, and applications in layered
    and three-dimensional cell culture systems to create\r\norganized tissue structures."
  description_type: abstract
  lang: en

## Creator

- name: Kazuhiko Ishihara
  role: author
  organization: Graduate School of Engineering, Osaka University,
  department: Division of Materials and Manufacturing Science

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## Publisher

organization: Taylor & Francis

## Managing organization



## Keyword

- subject: Stimuli-responsive hydrogel
  schema: not_defined
- subject: cytocompatibility
  schema: not_defined
- subject: cell encapsulation
  schema: not_defined
- subject: drug delivery system
  schema: not_defined
- subject: tissue engineering
  schema: not_defined

## Rights

- identifier: https://creativecommons.org/licenses/by-nc/4.0/

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## Data origin

- data_origin_type: other

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## Journal

- title: Science and Technology of Advanced Materials
  issn: '14686996'
  volume: '26'
  issue: '1'
  article_number: " 2469490"

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## Fileset

- id: 2e870afa-41a4-4705-9742-ace464d7bb2b
  filename: Advances in bioinspired polymer hydrogel systems with biomedical functionalities.pdf
  content_type: application/pdf
  size: 5042718
  md5: 64ee3695d0739b239790f4c46255f5de

## Thumbnail

fileset_id: 2e870afa-41a4-4705-9742-ace464d7bb2b
filename: Advances in bioinspired polymer hydrogel systems with biomedical functionalities.pdf