# Influence of microenvironmental viscosity on the cellular uptake of Fe                    <sub>3</sub>                    O                    <sub>4</sub>                    nanoparticles and their anticancer effect

https://mdr.nims.go.jp/datasets/df3d24c6-3d59-4b4a-9769-aa9ba0c35d94

## File

- [d5nr05112f.pdf](https://mdr.nims.go.jp/filesets/2d930fb0-cc72-451a-8d1a-f7ed9fe3c03e/download) ([Detail](https://mdr.nims.go.jp/filesets/2d930fb0-cc72-451a-8d1a-f7ed9fe3c03e.md))

## Id

df3d24c6-3d59-4b4a-9769-aa9ba0c35d94

## Local identifier



## Visibility

open_to_public

## State

published

## Created at

2026-07-14T07:49:33.576942Z

## Updated at

2026-07-14T23:23:46.893545Z

## Published at

2026-07-15T01:37:00.562680Z

## Doi



## First published url

https://doi.org/10.1039/d5nr05112f

## Date published

2026-04-28

## Recorded date published

2026-5-28

## Resource type

journal_article

## Manuscript type

vor

## Collection



## Title

- title: |-
    Influence of microenvironmental viscosity on the cellular uptake of Fe
                        <sub>3</sub>
                        O
                        <sub>4</sub>
                        nanoparticles and their anticancer effect
  title_type: original
  lang: en

## Description

- description: In this study, the effect of microenvironmental viscosity on the cellular
    uptake of magnetic nanoparticles and the efficiency of magnetic hyperthermia were
    investigated by culturing colorectal cancer cells in media of different viscosities.
    Results showed that the cellular uptake of magnetic nanoparticles significantly
    decreased with increasing microenvironmental viscosity, which further decreased
    the intracellular heating effect of magnetic nanoparticles. Furthermore, the proportion
    of apoptotic cells induced by magnetic hyperthermia was significantly reduced
    in high viscosity microenvironments, and the most viscous microenvironment exhibited
    the lowest apoptosis rate. This study revealed the important role of microenvironmental
    viscosity in regulating the cellular uptake of magnetic nanoparticles and the
    efficiency of magnetic hyperthermia.
  description_type: abstract
  lang: und

## Creator

- name: Man Wang
  role: author
- name: Huajian Chen
  role: author
  organization: National Institute for Materials Science
- name: Rui Sun
  role: author
- name: Tianjiao Zeng
  role: author
  orcid: https://orcid.org/0000-0002-1286-0337
  organization: National Institute for Materials Science
- name: Chengyu Lu
  role: author
- name: Toru Yoshitomi
  role: author
  orcid: https://orcid.org/0000-0003-3847-1812
  organization: National Institute for Materials Science
- name: Naoki Kawazoe
  role: author
  orcid: https://orcid.org/0000-0003-3916-0709
  organization: National Institute for Materials Science
- name: Yingnan Yang
  role: author
- name: Guoping Chen
  role: author
  orcid: https://orcid.org/0000-0001-6753-3678
  organization: National Institute for Materials Science

## Contact agent



## Publisher

organization: Royal Society of Chemistry (RSC)

## Managing organization



## Keyword

- subject: microenvironmental viscosity
  schema: not_defined
- subject: cellular uptake
  schema: not_defined
- subject: Fe3O4 nanoparticle
  schema: not_defined
- subject: anticancer effect
  schema: not_defined

## Rights

- identifier: https://creativecommons.org/licenses/by-nc/4.0/
  date_licensed: 2026-04-28

## Other identifier(s)



## Data origin



## Embargo



## Journal

- title: Nanoscale
  issn: '20403372'
  volume: '18'
  issue: '20'
  start_page: 10691
  end_page: 10702

## Conference



## Related item



## Funding

- identifier: 22K19926
  funder_name: Japan Society for the Promotion of Science
- identifier: 24K03289
  funder_name: Japan Society for the Promotion of Science

## Instrument



## Instrument operator



## Instrument managing organization



## Measurement method



## Specimen



## Chemical composition



## Structure for specimen



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## Process for specimen treatment



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## Fileset

- id: 2d930fb0-cc72-451a-8d1a-f7ed9fe3c03e
  filename: d5nr05112f.pdf
  content_type: application/pdf
  size: 3342764
  md5: e044f70e005bab388244da8e5d8ef401

## Thumbnail

fileset_id: 2d930fb0-cc72-451a-8d1a-f7ed9fe3c03e
filename: d5nr05112f.pdf