# Vision of Life’s Code: Molecular Probe Nanoarchitectonics for Deep RNA/DNA Illumination

https://mdr.nims.go.jp/datasets/d7dfe003-1eb5-4f2b-bcf3-8f68bb4e6ca9

## Files

- [ACSNano26_20_6493.pdf](https://mdr.nims.go.jp/filesets/5a72db56-3c17-4af1-9312-7f791ec9f7fd/download) ([Detail](https://mdr.nims.go.jp/filesets/5a72db56-3c17-4af1-9312-7f791ec9f7fd.md))

## Id

d7dfe003-1eb5-4f2b-bcf3-8f68bb4e6ca9

## Local identifier



## Visibility

open_to_public

## State

published

## Created at

2026-03-04T02:20:57.891661Z

## Updated at

2026-03-04T23:30:16.221764Z

## Published at

2026-03-04T09:12:11.104275Z

## Doi



## First published url

https://doi.org/10.1021/acsnano.5c22282

## Date published

2026-03-03

## Recorded date published

2026-3-3

## Resource type

journal_article

## Manuscript type

vor

## Collection



## Title

- title: 'Vision of Life’s Code: Molecular Probe Nanoarchitectonics for Deep RNA/DNA
    Illumination'
  title_type: original
  lang: en

## Description

- description: 'Visualization of RNA and DNA provides a window of opportunity for
    earlier detection of multiple diseases and approach to manipulate it before any
    pathological processes occur. Yet, current imaging systems often fail to meet
    these demands due to need of multiple RNA and DNA chemical probes, which increases
    experimental complexity, reduces awareness of false positives, and limits imaging
    accuracy in complex biosystems. In this progress, we identify the key challenges
    associated with using multiple probes for RNA and DNA imaging and analyze the
    mechanisms and performance of existing imaging tools. This article also introduces
    a conceptual framework and proposes a multidisciplinary framework to guide the
    next generation of imaging technologies. Furthermore, we highlight how nanoarchitectonics-based
    molecular design can enable single-step, multiplexed RNA–DNA imaging. Our goal
    is to provide valuable resource for both biologists and probe developers for choosing
    the suitable molecular probes and further advance their design, from initial concepts
    to commercial products—all from a biologist’s perspective. '
  description_type: abstract
  lang: und

## Creator

- name: Linawati Sutrisno
  role: author
  orcid: https://orcid.org/0000-0003-3085-9660
- name: Kewei Sun
  role: author
  orcid: https://orcid.org/0000-0002-1835-243X
- name: Katsuhiko Ariga
  role: author
  orcid: https://orcid.org/0000-0002-2445-2955

## Contact agent



## Publisher

organization: American Chemical Society (ACS)

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## Keyword

- subject: RNA
  schema: not_defined
- subject: DNA
  schema: not_defined
- subject: bioimaging, chemical probes
  schema: not_defined
- subject: multiplex, in vitro
  schema: not_defined
- subject: biologist
  schema: not_defined
- subject: chemist
  schema: not_defined
- subject: detection
  schema: not_defined

## Rights

- identifier: https://creativecommons.org/licenses/by/4.0/

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## Embargo



## Journal

- title: ACS Nano
  issn: '19360851'
  volume: '20'
  issue: '8'
  start_page: 6493
  end_page: 6514

## Conference



## Related item



## Funding

- identifier: JP24KF0089
  funder_name: Japan Society for the Promotion of Science
- identifier: JP25H00898
  funder_name: Japan Society for the Promotion of Science
- identifier: JP25K23571
  funder_name: Japan Society for the Promotion of Science
- funder_name: ICYS project

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## Fileset

- id: 5a72db56-3c17-4af1-9312-7f791ec9f7fd
  filename: ACSNano26_20_6493.pdf
  content_type: application/pdf
  size: 5223895
  md5: c94f5fd1d34946a76f48c2186131a661

## Thumbnail

fileset_id: 5a72db56-3c17-4af1-9312-7f791ec9f7fd
filename: ACSNano26_20_6493.pdf