# The Effect of Metal Materials on Heat Shock Protein 70B’ Gene Expression

https://mdr.nims.go.jp/datasets/d766d33f-52fd-406b-815b-9b694e795951

## File

- [14TOBIOTJ.pdf](https://mdr.nims.go.jp/filesets/f539ea5e-9396-47b1-a876-6f35e88a7447/download) ([Detail](https://mdr.nims.go.jp/filesets/f539ea5e-9396-47b1-a876-6f35e88a7447.md))

## Id

d766d33f-52fd-406b-815b-9b694e795951

## Local identifier



## Visibility

open_to_public

## State

published

## Created at

2025-09-17T10:13:59.097901Z

## Updated at

2025-09-18T03:30:21.359546Z

## Published at

2025-09-18T03:23:06.271048Z

## Doi



## First published url

https://doi.org/10.2174/1874070700701010014

## Date published

2007-06-20

## Recorded date published

2007-6-20

## Resource type

journal_article

## Manuscript type

vor

## Collection



## Title

- title: The Effect of Metal Materials on Heat Shock Protein 70B’ Gene Expression
  title_type: original
  lang: en

## Description

- description: To avoid the toxic effect of released nickel ions and compounds from
    conventional stainless steels, nickel-free austenitic stainless steels have been
    developed. We previously established a new manufacturing process to produce nickel-free
    austenitic stainless steel that involves nitrogen adsorption treatment. Although
    the cytocompatibility of nickel-free austenitic stainless steel produced using
    this method has been evaluated using two viability assay, molecular level analysis,
    such as gene expression analysis, has not been previously performed. In the present
    study, the cytotoxicity of our nickel-free austenitic stainless steel, as well
    as of commercially available metal materials, was evaluated by analysis of heat
    shock protein 70B’ (HSP70B’) gene expression as a stress response marker.
  description_type: abstract
  lang: und

## Creator

- name: Junko Okuda-Shimazaki
  role: author
- name: Akiko Yamamoto
  role: author
  orcid: https://orcid.org/0000-0002-9182-4886
  organization: National Institute for Materials Science
- name: Daisuke Kuroda
  role: author
- name: Takao Hanawa
  role: author
- name: Akiyoshi Taniguchi
  role: author
  orcid: https://orcid.org/0000-0001-7835-2522
  organization: National Institute for Materials Science

## Contact agent



## Publisher

organization: Bentham Science Publishers Ltd.

## Managing organization



## Keyword

- subject: Heat Shock Protein 70B’
  schema: not_defined
- subject: cytocompatibility
  schema: not_defined
- subject: human osteoblast-like SaOS-2 cells
  schema: not_defined
- subject: human monocyte THP-1 cells
  schema: not_defined

## Rights

- identifier: https://creativecommons.org/licenses/by/4.0/

## Other identifier(s)



## Data origin

- data_origin_type: other

## Embargo



## Journal

- title: The Open Biotechnology Journal
  issn: '18740715'
  volume: '1'
  start_page: 14
  end_page: 17

## Conference



## Related item



## Funding



## Instrument



## Instrument operator



## Instrument managing organization



## Measurement method



## Specimen



## Chemical composition



## Structure for specimen



## Structural feature for specimen



## Specific property for specimen



## Process for specimen treatment



## Computational method



## Energy level/transition state



## Software



## Custom property



## Fileset

- id: f539ea5e-9396-47b1-a876-6f35e88a7447
  filename: 14TOBIOTJ.pdf
  content_type: application/pdf
  size: 503837
  md5: 35bd743283837064aff644919d3567ab

## Thumbnail

fileset_id: f539ea5e-9396-47b1-a876-6f35e88a7447
filename: 14TOBIOTJ.pdf