# The effect of branched structures of alkyl groups on tissue adhesiveness and biocompatibility of alkyl groups-modified Alaska pollock gelatin-based adhesives

https://mdr.nims.go.jp/datasets/ce50541a-2a69-40b2-9a05-057b9e5f9bfe

## File

- [JMADE-D-25-02817_R1-MDR.pdf](https://mdr.nims.go.jp/filesets/b9610f72-9a6e-4989-ad45-4138c8f51acf/download) ([Detail](https://mdr.nims.go.jp/filesets/b9610f72-9a6e-4989-ad45-4138c8f51acf.md))

## Id

ce50541a-2a69-40b2-9a05-057b9e5f9bfe

## Local identifier



## Visibility

open_to_public

## State

published

## Created at

2025-08-29T07:46:10.699369Z

## Updated at

2025-11-17T23:30:03.810666Z

## Published at

2025-11-17T23:22:59.254136Z

## Doi

https://doi.org/10.48505/nims.5911

## First published url

https://doi.org/10.1016/j.matdes.2025.114665

## Date published

2025-09-11

## Recorded date published

2025-10

## Resource type

journal_article

## Manuscript type

accepted_manuscript

## Collection



## Title

- title: The effect of branched structures of alkyl groups on tissue adhesiveness
    and biocompatibility of alkyl groups-modified Alaska pollock gelatin-based adhesives
  title_type: original
  lang: en

## Description

- description: Tissue adhesives are widely used to prevent air leakage from the lungs
    and bleeding from vascular anastomoses. However, currently used tissue adhesives
    still face challenges with either tissue adhesion or biocompatibility. We previously
    reported tissue adhesives composed of straight alkyl group-modified Alaska pollock
    gelatin (ApGltn) and pentaerythritol poly (ethylene glycol) ether tetrasuccinimidyl
    glutarate (4S-PEG). The developed adhesives have sufficient tissue adhesive strength
    and biocompatibility for biomedical applications; however, the effect of the branched
    structures of the alkyl groups on these functions has not yet been clarified.
    In this study, we evaluated the tissue adhesiveness and biocompatibility of three
    tissue adhesives based on straight/branched alkyl group-modified ApGltns and 4S-PEG.
    The results showed that branched alkyl group-modified ApGltns-based adhesives
    had higher tissue adhesion strength than straight alkyl-ApGltn. Furthermore, the
    burst strength of the branched alkyl group modified ApGltn-based adhesives 2-fold
    higher compared to commercial Fibrin. In addition, they were completely biodegraded
    in rat subcutaneous tissue within 56 days without causing severe inflammation.
  description_type: abstract
  lang: eng

## Creator

- name: Satsuki Minamisakamoto
  role: author
- name: Hiyori Komatsu
  role: author
  orcid: https://orcid.org/0000-0002-2525-1362
  organization: National Institute for Materials Science
- name: Shiharu Watanabe
  role: author
  organization: National Institute for Materials Science
- name: Shima Ito
  role: author
  orcid: https://orcid.org/0000-0002-3233-617X
  organization: National Institute for Materials Science
- name: Hatsune Nishino
  role: author
- name: Tetsushi Taguchi
  role: author
  orcid: https://orcid.org/0000-0003-2541-2530
  organization: National Institute for Materials Science

## Contact agent



## Publisher

organization: Elsevier BV

## Managing organization



## Keyword

- subject: in situ hydrogel
  schema: not_defined
- subject: tissue adhesion
  schema: not_defined
- subject: Alaska pollock-derived gelatin
  schema: not_defined

## Rights

- identifier: https://creativecommons.org/licenses/by/4.0/

## Other identifier(s)



## Data origin

- data_origin_type: other

## Embargo



## Journal

- title: Materials & Design
  issn: '02641275'
  volume: '258'
  article_number: '114665'

## Conference



## Related item



## Funding

- identifier: 24K21677
  funder_name: Japan Society for the Promotion of Science
- identifier: 22KJ0418
  funder_name: Japan Society for the Promotion of Science
- identifier: 23K26411
  funder_name: Japan Society for the Promotion of Science
- identifier: 24KJ0500
  funder_name: Japan Society for the Promotion of Science
- identifier: 23K25216
  funder_name: Japan Society for the Promotion of Science
- identifier: 24K22399
  funder_name: Japan Society for the Promotion of Science

## Instrument



## Instrument operator



## Instrument managing organization



## Measurement method



## Specimen



## Chemical composition



## Structure for specimen



## Structural feature for specimen



## Specific property for specimen



## Process for specimen treatment



## Computational method



## Energy level/transition state



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## Custom property



## Fileset

- id: b9610f72-9a6e-4989-ad45-4138c8f51acf
  filename: JMADE-D-25-02817_R1-MDR.pdf
  content_type: application/pdf
  size: 2766960
  md5: e8d7ead8c0e3c248af77216155d4bf69

## Thumbnail

fileset_id: b9610f72-9a6e-4989-ad45-4138c8f51acf
filename: JMADE-D-25-02817_R1-MDR.pdf