# Bioactive Alkaloids from Nepalese <i>Corydalis chaerophylla</i> D.C. Acting on the Regulation of PCSK9 and LDL‐R <i>In Vitro</i>

https://mdr.nims.go.jp/datasets/cb0927bd-d371-4fd6-a1b1-befaba53ea4a

## File

- [ChemBiodiversity24_ 21_e20240138.pdf](https://mdr.nims.go.jp/filesets/0a883867-d079-4ab7-878c-b00f47bedfb6/download) ([Detail](https://mdr.nims.go.jp/filesets/0a883867-d079-4ab7-878c-b00f47bedfb6.md))

## Id

cb0927bd-d371-4fd6-a1b1-befaba53ea4a

## Local identifier



## Visibility

open_to_public

## State

published

## Created at

2024-12-16T10:25:01.948416Z

## Updated at

2024-12-18T07:30:36.334594Z

## Published at

2024-12-18T23:30:37.233522Z

## Doi



## First published url

https://doi.org/10.1002/cbdv.202401388

## Date published

2024-10-28

## Recorded date published

2024-12

## Resource type

journal_article

## Manuscript type

vor

## Collection



## Title

- title: Bioactive Alkaloids from Nepalese <i>Corydalis chaerophylla</i> D.C. Acting
    on the Regulation of PCSK9 and LDL‐R <i>In Vitro</i>
  title_type: original
  lang: en

## Description

- description: The new alkaloids were tested in human hepatoma cell line to assess
    their ability to modulate the expression of low-density lipoprotein receptor (LDL-R),
    of proprotein convertase subtilisin/kexin 9 (PCSK9)  and to affect cellular cholesterol
    biosynthesis with the aim to evaluate their potential hypocholesterolemic effect.
  description_type: abstract
  lang: und

## Creator

- name: Binita Maharjan
  role: author
- name: Ilaria Rossi
  role: author
- name: Stefania Sut
  role: author
- name: Timila Shrestha
  role: author
- name: Lok Kumar Shrestha
  role: author
  orcid: https://orcid.org/0000-0003-2680-6291
  organization: National Institute for Materials Science
  ror: https://ror.org/026v1ze26
- name: Jonathan P. Hill
  role: author
  orcid: https://orcid.org/0000-0002-4229-5842
  organization: National Institute for Materials Science
  ror: https://ror.org/026v1ze26
- name: Katsuhiko Ariga
  role: author
  orcid: https://orcid.org/0000-0002-2445-2955
  organization: National Institute for Materials Science
  ror: https://ror.org/026v1ze26
- name: Veronica Benetazzo
  role: author
- name: Maria Pia Adorni
  role: author
- name: Bianca Papotti
  role: author
- name: Shyam Sharan Shrestha
  role: author
- name: Ram Lal Swagat Shrestha
  role: author
- name: Nicola Ferri
  role: author
- name: Stefano Dall'Acqua
  role: author

## Contact agent



## Publisher

organization: Wiley

## Managing organization



## Keyword

- subject: Isoquinoline alkaloids
  schema: not_defined
- subject: Corydalis chaerophylla D.C.
  schema: not_defined
- subject: PCSK9
  schema: not_defined
- subject: LDL- R
  schema: not_defined

## Rights

- identifier: https://creativecommons.org/licenses/by-nc/4.0/

## Other identifier(s)



## Data origin

- data_origin_type: other

## Embargo



## Journal

- title: Chemistry & Biodiversity
  issn: '16121872'
  volume: '21'
  issue: '12'
  article_number: e202401388

## Conference



## Related item



## Funding



## Instrument



## Instrument operator



## Instrument managing organization



## Measurement method



## Specimen



## Chemical composition



## Structure for specimen



## Structural feature for specimen



## Specific property for specimen



## Process for specimen treatment



## Computational method



## Energy level/transition state



## Software



## Custom property



## Fileset

- id: 0a883867-d079-4ab7-878c-b00f47bedfb6
  filename: ChemBiodiversity24_ 21_e20240138.pdf
  content_type: application/pdf
  size: 1456055
  md5: ab6bf44e788f62be0a47532490993ea4

## Thumbnail

fileset_id: 0a883867-d079-4ab7-878c-b00f47bedfb6
filename: ChemBiodiversity24_ 21_e20240138.pdf