# Nanoporous Dna Field Effect Transistor with Potential for Random‐Access Memory Applications: A Selectivity Performance Evaluation

https://mdr.nims.go.jp/datasets/c84807ed-52e2-4544-adae-5795f9027573

## File

- [Advanced Sensor Research - DNA sensor Volkan.pdf](https://mdr.nims.go.jp/filesets/936dfad1-2f6f-4f8b-91e6-ee17415bc17f/download) ([Detail](https://mdr.nims.go.jp/filesets/936dfad1-2f6f-4f8b-91e6-ee17415bc17f.md))

## Id

c84807ed-52e2-4544-adae-5795f9027573

## Local identifier



## Visibility

open_to_public

## State

published

## Created at

2024-08-09T07:39:51.817494Z

## Updated at

2024-08-19T07:30:24.028890Z

## Published at

2024-08-19T07:30:24.124745Z

## Doi



## First published url

https://doi.org/10.1002/adsr.202300176

## Date published

2024-02-02

## Recorded date published

2024-5

## Resource type

journal_article

## Manuscript type

vor

## Collection



## Title

- title: 'Nanoporous Dna Field Effect Transistor with Potential for Random‐Access
    Memory Applications: A Selectivity Performance Evaluation'
  title_type: original
  lang: en

## Description

- description: "Methods to encode digital data items as strands of synthetic DNA followed
    by selective data retrieval have been demonstrated. However, these initially bio-oriented
    processes remain slow and not optimized. DNA field-effect transistor (DNA-FET)
    is studied here as a possible random-access memory (RAM) device for simple, selective
    and rapid ssDNA fragment retrieval used as data pool identifier. The DNA-FET is
    based on a co-planar Au-gated fully organic transistor appended with short single-stranded
    DNA (ssDNA) probes bearing a blocking molecule to prevent partial hybridization
    and achieve near perfect selectivity for short length ssDNA (up to 45 nt). Examination
    of transconductance of the novel active layer incorporating a DNA nanopore architecture
    reveals enhanced binding site accessibility. This, in turn, facilitates discriminatory
    hybridization, particularly in the physical retrieval of short-length ssDNA from
    a competitive, concentrated ssDNA background pool consisting of nine different
    sequences, with at least one nucleotide difference. The DNA-FET exhibits rapid
    operation (9 min) in the millivolt range, low detection limit (sub-femtomolar),
    high selectivity and reusability. Considering the straightforward concept, near
    error-free identification\r\ncapacity and hypothetically outstanding scalability,
    the DNA-FET described here has potential as a foundation for further exploration
    of advanced RAM technology in the DNA data storage process. "
  description_type: abstract
  lang: und

## Creator

- name: Volkan Kilinc
  role: author
- name: Ryoma Hayakawa
  role: author
  orcid: https://orcid.org/0000-0002-1442-8230
  organization: National Institute for Materials Science
  ror: https://ror.org/026v1ze26
- name: Yusuke Yamauchi
  role: author
  organization: National Institute for Materials Science
  ror: https://ror.org/026v1ze26
- name: Yutaka Wakayama
  role: author
  orcid: https://orcid.org/0000-0002-0801-8884
  organization: National Institute for Materials Science
  ror: https://ror.org/026v1ze26
- name: Jonathan P. Hill
  role: author
  orcid: https://orcid.org/0000-0002-4229-5842
  organization: National Institute for Materials Science
  ror: https://ror.org/026v1ze26

## Contact agent



## Publisher

organization: Wiley

## Managing organization



## Keyword

- subject: DNA
  schema: not_defined
- subject: Field effect transistor
  schema: not_defined
- subject: Random access memory
  schema: not_defined

## Rights

- identifier: https://creativecommons.org/licenses/by/4.0/

## Other identifier(s)



## Data origin

- data_origin_type: other

## Embargo



## Journal

- title: Advanced Sensor Research
  issn: '27511219'
  volume: '3'
  issue: '5'
  start_page: 1
  end_page: 14
  article_number: '2300176'

## Conference



## Related item



## Funding

- funder_name: Japan Society for the Promotion of Science
- funder_name: Ministry of Education, Culture, Sports, Science and Technology

## Instrument



## Instrument operator



## Instrument managing organization



## Measurement method



## Specimen



## Chemical composition



## Structure for specimen



## Structural feature for specimen



## Specific property for specimen



## Process for specimen treatment



## Computational method



## Energy level/transition state



## Software



## Custom property



## Fileset

- id: 936dfad1-2f6f-4f8b-91e6-ee17415bc17f
  filename: Advanced Sensor Research - DNA sensor Volkan.pdf
  content_type: application/pdf
  size: 4498898
  md5: 191af298156ebe3cd6c0404282664350

## Thumbnail

fileset_id: 936dfad1-2f6f-4f8b-91e6-ee17415bc17f
filename: Advanced Sensor Research - DNA sensor Volkan.pdf