# Locally implantable nanofibre meshes by sustained release of temozolomide for combined thermo-chemotherapy to treat glioblastoma

https://mdr.nims.go.jp/datasets/c7d1bcf6-d6f7-4e00-8cb4-538aa35dfe26

## File

- [MS_New Journal of Chemistry_Oe.pdf](https://mdr.nims.go.jp/filesets/3dc097c5-53f4-453a-9645-81fc49c96637/download) ([Detail](https://mdr.nims.go.jp/filesets/3dc097c5-53f4-453a-9645-81fc49c96637.md))

## Id

c7d1bcf6-d6f7-4e00-8cb4-538aa35dfe26

## Local identifier



## Visibility

open_to_public

## State

published

## Created at

2024-08-19T10:50:56.329191Z

## Updated at

2024-10-11T03:30:30.266284Z

## Published at

2024-10-11T03:30:30.496943Z

## Doi

https://doi.org/10.48505/nims.4836

## First published url

https://doi.org/10.1039/d3nj00534h

## Date published

2023-02-21

## Recorded date published

2023-3-20

## Resource type

journal_article

## Manuscript type

accepted_manuscript

## Collection



## Title

- title: Locally implantable nanofibre meshes by sustained release of temozolomide
    for combined thermo-chemotherapy to treat glioblastoma
  title_type: original
  lang: en

## Description

- description: Glioblastoma (GBM) is a highly malignant type of brain tumour that
    arises from astrocytes or supportive brain tissue in adults. Although there are
    several therapeutic options, recurrence rates remain high, with a 5 year survival
    rate expectancy of less than 10%. This study investigates nanofibre meshes that
    enable the long-term release of temozolomide (TMZ) over a 4 week period by controlling
    the fibre morphologies. The nanofibre meshes were fabricated via the electrospinning
    of a biodegradable polymer, poly(ε-caprolactone) (PCL). The obtained meshes were
    flexible and implantable as a local intracranial drug delivery platform. The nanofibre
    meshes also carry magnetic nanoparticles (MNPs) that enable the combined therapy
    of hyperthermia/chemotherapy corresponding to an alternating magnetic field (AMF).
    The heat generation behaviour of the nanofibre meshes was successfully adjusted
    in a hyperthermic temperature range (∼42.6 °C). The TMZ/MNP-loaded nanofibre meshes
    showed a 76% reduction in the cell viability of GBM cancer (T98G) cells through
    the synergistic effect of hyperthermia and chemotherapy. These results indicated
    the potential applications of nanofibre meshes as an implantable intracranial
    drug delivery system as an adjunct to surgery and radiation for GBM patients.
  description_type: abstract
  lang: und

## Creator

- name: Emiho Oe
  role: author
  orcid: https://orcid.org/0000-0001-7326-7740
  organization: National Institute for Materials Science
- name: Nanami Fujisawa
  role: author
  orcid: https://orcid.org/0000-0002-8894-1790
  organization: National Institute for Materials Science
- name: Lili Chen
  role: author
  orcid: https://orcid.org/0000-0001-8290-5230
  organization: National Institute for Materials Science
- name: Koichiro Uto
  role: author
  orcid: https://orcid.org/0000-0001-7091-0585
  organization: National Institute for Materials Science
- name: Yoshitaka Matsumoto
  role: author
  orcid: https://orcid.org/0000-0002-2074-3042
- name: Mitsuhiro Ebara
  role: author
  orcid: https://orcid.org/0000-0002-7906-0350
  organization: National Institute for Materials Science

## Contact agent



## Publisher

organization: Royal Society of Chemistry (RSC)

## Managing organization



## Keyword

- subject: chemotherapy
  schema: not_defined
- subject: glioblastoma
  schema: not_defined
- subject: cancer
  schema: not_defined
- subject: nanofibers
  schema: not_defined

## Rights

- identifier: http://rightsstatements.org/vocab/InC/1.0/

## Other identifier(s)



## Data origin

- data_origin_type: other

## Embargo

start_date: 2023-02-21
end_date: 2024-02-21

## Journal

- title: New Journal of Chemistry
  issn: '13699261'
  volume: '47'
  issue: '12'
  start_page: 5816
  end_page: 5824

## Conference



## Related item



## Funding

- identifier: Grant-in-Aid for Scientific Research (B) [JP19H04476]
  funder_name: Japan Society for the Promotion of Science
- identifier: Grant-in-Aid for Transformative Research Areas (A) [JP20H05877]
  funder_name: Japan Society for the Promotion of Science

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## Fileset

- id: 3dc097c5-53f4-453a-9645-81fc49c96637
  filename: MS_New Journal of Chemistry_Oe.pdf
  content_type: application/pdf
  size: 1493724
  md5: 0dfa82f67cd386c4c8310e7175616d20

## Thumbnail

fileset_id: 3dc097c5-53f4-453a-9645-81fc49c96637
filename: MS_New Journal of Chemistry_Oe.pdf