# Highly Deformable Phototunable Viscoelastic Fluid Interface Modulates Cellular Adaptive Wetting Behavior

https://mdr.nims.go.jp/datasets/c7c213d7-be40-46ed-8b50-6ad79de68d7c

## File

- [Adv Funct Materials - 2025 - Zhou - Highly Def.pdf](https://mdr.nims.go.jp/filesets/c56dcdb9-721e-4539-b5eb-9c26bf1d8fbe/download) ([Detail](https://mdr.nims.go.jp/filesets/c56dcdb9-721e-4539-b5eb-9c26bf1d8fbe.md))

## Id

c7c213d7-be40-46ed-8b50-6ad79de68d7c

## Local identifier



## Visibility

open_to_public

## State

published

## Created at

2025-06-09T22:44:42.629685Z

## Updated at

2025-06-10T03:30:22.445993Z

## Published at

2025-06-10T03:22:44.080993Z

## Doi



## First published url

https://doi.org/10.1002/adfm.202414534

## Date published

2025-01-16

## Recorded date published

2025-2

## Resource type

journal_article

## Manuscript type

vor

## Collection



## Title

- title: Highly Deformable Phototunable Viscoelastic Fluid Interface Modulates Cellular
    Adaptive Wetting Behavior
  title_type: original
  lang: en

## Description

- description: A fluid-based scaffold with tunable viscoelasticity has been developed
    to investigate its impact on the cell adhesion process. The platform is based
    on the water–perfluorocarbon interface decorated with diacetylene-based phospholipid
    membranes (IPLMs), whose viscoelasticity can be systematically manipulated by
    photocrosslinking. Further introduction of a cell-adhesive peptide and fluorescent
    tag allows cell adhesion at the highly deformable fluid interface and confocal
    observation of dynamic cell–model ECM interactions. Cells seeded at the IPLM exhibit
    so-called adaptive wetting, where the interface first deforms toward the out-of-plane
    direction before cellular dimensional changes, followed by cellular flattening
    and interfacial restoration. Furthermore, the quantification of these parameters
    reveals a biphasic response against the crosslinking levels, which indicates that
    the cell-ECM viscosity balance determines adaptive wetting phenotypes.
  description_type: abstract
  lang: und

## Creator

- name: Junhong Zhou
  role: author
  orcid: https://orcid.org/0000-0001-6327-6512
- name: Hongxin Wang
  role: author
  orcid: https://orcid.org/0000-0002-8984-0764
- name: Jun Nakanishi
  role: author
  orcid: https://orcid.org/0000-0003-4457-6581

## Contact agent



## Publisher

organization: Wiley

## Managing organization



## Keyword

- subject: Mechanobiology
  schema: not_defined
- subject: Cell Adhesion
  schema: not_defined
- subject: Fluid
  schema: not_defined
- subject: Cell Scaffold
  schema: not_defined
- subject: Viscoelasticity
  schema: not_defined

## Rights

- identifier: https://creativecommons.org/licenses/by/4.0/

## Other identifier(s)



## Data origin



## Embargo



## Journal

- title: Advanced Functional Materials
  issn: 1616301X
  volume: '35'
  issue: '7'

## Conference



## Related item



## Funding

- identifier: 22H00596
  funder_name: Japan Society for the Promotion of Science
- identifier: 23K17481
  funder_name: Japan Society for the Promotion of Science
- identifier: 23KJ2167
  funder_name: Japan Society for the Promotion of Science

## Instrument



## Instrument operator



## Instrument managing organization



## Measurement method



## Specimen



## Chemical composition



## Structure for specimen



## Structural feature for specimen



## Specific property for specimen



## Process for specimen treatment



## Computational method



## Energy level/transition state



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## Custom property



## Fileset

- id: c56dcdb9-721e-4539-b5eb-9c26bf1d8fbe
  filename: Adv Funct Materials - 2025 - Zhou - Highly Def.pdf
  content_type: application/pdf
  size: 4494316
  md5: 79dac35eaa919b5e5ccc74ee5cd78c2e

## Thumbnail

fileset_id: c56dcdb9-721e-4539-b5eb-9c26bf1d8fbe
filename: Adv Funct Materials - 2025 - Zhou - Highly Def.pdf