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説明:

In this Account, we present a historical overview of the evolution of our unique molecular imaging toolbox, tracing its development from fundamental studies of molecular recognition in artificial systems to multiplex visualization of organelle dynamics in living cells, and ultimately to their successful translation into bioimaging probes. Our early efforts established how hydrogen-bonding interactions at artificial lipid membrane interfaces can be exploited to enhance biomolecular recognition under aqueous conditions. These studies further revealed that tuning membrane mechanical properties provides a powerful strategy for discriminating structurally similar nucleotide targets and regulating selective molecular recognition. The principles derived from these artificial systems were subsequently extended to fluorescence sensing platforms for recognition of biologically relevant analytes.

権利情報:

• Creative Commons BY Attribution 4.0 International
  

キーワード: Imaging, Cell, Nanoarchitectonics, Ladder-Type π-Conjugate, Heteroatom

刊行年月日: 2026-10-23

出版者: American Chemical Society (ACS)

掲載誌:

• Accounts of Materials Research (ISSN: 26436728) vol. 7 issue. 10 p. 1074-1088

研究助成金:

• Core Research for Evolutional Science and Technology JRMJCR21O5
• Japan Society for the Promotion of Science 22K21346
• Japan Society for the Promotion of Science 25H00898
• Japan Society for the Promotion of Science 25H01261
• Japan Society for the Promotion of Science 25K23571
• Japan Society for the Promotion of Science 26K01643
• Japan Society for the Promotion of Science 26K15594
• Japan Society for the Promotion of Science JP23H05459

原稿種別: 出版者版 (Version of record)

MDR DOI:

公開URL: https://doi.org/10.1021/accountsmr.6c00184

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更新時刻: 2026-10-24 09:40:54 +0900

MDRでの公開時刻: 2026-10-26 12:26:34 +0900