# Noninvasive Needle-Free Cancer Vaccine Cream Patch Based on Fluorinated Chitosan https://mdr.nims.go.jp/datasets/c5908acd-8754-474b-86fc-4314711ae65b ## File - [AMF-2024.docx](https://mdr.nims.go.jp/filesets/d76b8a75-7238-4da4-9e3b-f6c37e063d25/download) ([Detail](https://mdr.nims.go.jp/filesets/d76b8a75-7238-4da4-9e3b-f6c37e063d25.md)) ## Id c5908acd-8754-474b-86fc-4314711ae65b ## Local identifier ## Visibility open_to_public ## State published ## Created at 2024-10-24T01:06:52.120961Z ## Updated at 2024-12-22T03:30:29.804130Z ## Published at 2024-12-22T03:30:30.313219Z ## Doi https://doi.org/10.48505/nims.4888 ## First published url https://doi.org/10.1002/adfm.202314022 ## Date published 2023-12-22 ## Recorded date published 2024-4 ## Resource type journal_article ## Manuscript type accepted_manuscript ## Collection ## Title - title: Noninvasive Needle-Free Cancer Vaccine Cream Patch Based on Fluorinated Chitosan title_type: original lang: en ## Description - description: In recent years, cancer vaccines that intend to specifically initiate host immune responses against cancer have achieved some clinical success. Delivery of vaccines with traditional needles is usually associated with the risk of infection and poor patient compliance. The development of needle-free vaccines may overcome these limitations. In this work, a needle-free patch is designed for effective cancer vaccination using a fluorine chain-modified cationic polymer, fluorinated chitosan (FCS), which is able to transdermatically deliver the antigen to antigen-presenting cells in the skin. Specifically, a transdermal carrier, FCS, and model antigen ovalbumin (OVA) can self-assemble into nanoparticles, which can reversibly open the tight junction-associated proteins of epithelial cells and penetrate across the epidermis. The needle-free cancer vaccine patch is fabricated by mixing FCS-OVA nanoparticles with the US Food and Drug Administration-approved immune adjuvant imiquimod (R837) in blank cream. Such a needle-free cancer vaccine can generate robust immune responses to protect mice against ovalbumin-expressing melanoma (B16-OVA). Compared to traditional intradermal injection, needle-free cancer vaccines achieved an even more efficient protection effect against B16-OVA cancer cells. This work indicated that the novel needle-free cancer vaccine may provide a compelling technology for simple and safe vaccination, which may help to increase vaccination coverage. description_type: abstract lang: eng ## Creator - name: Zhisheng Xiao role: author organization: School of Life and Environmental Sciences Degree Programs in Life and Earth Sciences Faculty of Life and Environmental Sciences, University of Tsukuba - name: Guangzhi Li role: author organization: Shenzhen University - name: Dashi Deng role: author organization: Shenzhen University - name: Ting Wei role: author organization: Soochow University - name: Guoping Chen role: author orcid: https://orcid.org/0000-0001-6753-3678 organization: National Institute for Materials Science department: Research Center for Macromolecules and Biomaterials/Biomaterials Field/Tissue Regeneration Materials Group ror: https://ror.org/026v1ze26 - name: Huiquan Tao role: author organization: Soochow University - name: Yu Chao role: author organization: Soochow University - name: Bo Liu role: author organization: Soochow University - name: Qiaofeng Li role: author organization: Soochow University - name: Yifan Yang role: author organization: Soochow University - name: Zhuang Liu role: author organization: Soochow University - name: Qian Chen role: author organization: Soochow University ## Contact agent ## Publisher organization: Wiley-Blackwell ## Managing organization ## Keyword - subject: cancer immunotherapy schema: not_defined - subject: fluorinated chitosan schema: not_defined - subject: needle-free vaccines schema: not_defined - subject: transdermal delivery schema: not_defined ## Rights - description: 'This is the peer reviewed version of the following article: Z. Xiao, G. Li, D. Deng, T. Wei, G. Chen, H. Tao, Y. Chao, B. Liu, Q. Li, Y. Yang, Z. Liu, Q. Chen, Noninvasive Needle-Free Cancer Vaccine Cream Patch Based on Fluorinated Chitosan. Adv. Funct. Mater. 2024, 34, 2314022, which has been published in final form at https://doi.org/10.1002/adfm.202314022. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages thereof by third parties from platforms, services and websites other than Wiley Online Library must be prohibited.' identifier: http://rightsstatements.org/vocab/InC/1.0/ ## Other identifier(s) ## Data origin - data_origin_type: other ## Embargo start_date: 2023-12-22 end_date: 2024-12-22 ## Journal - title: ADVANCED FUNCTIONAL MATERIALS issn: 1616301X volume: '34' issue: '17' start_page: 1 end_page: 12 ## Conference ## Related item ## Funding ## Instrument ## Instrument operator ## Instrument managing organization ## Measurement method ## Specimen ## Chemical composition ## Structure for specimen ## Structural feature for specimen ## Specific property for specimen ## Process for specimen treatment ## Computational method ## Energy level/transition state ## Software ## Custom property ## Fileset - id: d76b8a75-7238-4da4-9e3b-f6c37e063d25 filename: AMF-2024.docx content_type: application/vnd.openxmlformats-officedocument.wordprocessingml.document size: 8078475 md5: 8d5ffaf3605aeb09b92ab5da69ca75ef ## Thumbnail fileset_id: d76b8a75-7238-4da4-9e3b-f6c37e063d25 filename: AMF-2024.docx