# Precipitative Coating of Calcium Phosphate on Microporous Silica–Titania Hybrid Particles in Simulated Body Fluid

https://mdr.nims.go.jp/datasets/c44670b6-e400-47b1-bd7e-60ee589d91bc

## File

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## Id

c44670b6-e400-47b1-bd7e-60ee589d91bc

## Local identifier



## Visibility

open_to_public

## State

published

## Created at

2024-11-18T05:20:23.357220Z

## Updated at

2024-11-20T09:40:02.134456Z

## Published at

2024-11-20T09:40:02.360590Z

## Doi



## First published url

https://doi.org/10.3390/inorganics11060235

## Date published

2023-05-28

## Recorded date published



## Resource type

journal_article

## Manuscript type

vor

## Collection



## Title

- title: Precipitative Coating of Calcium Phosphate on Microporous Silica–Titania
    Hybrid Particles in Simulated Body Fluid
  title_type: original
  lang: en

## Description

- description: Titania and silica have been recognized as potential drug delivery
    system (DDS) carriers. For this application, controllable biocompatibility and
    the suppression of the initial burst are required, which can be provided by a
    calcium phosphate (CP) coating. However, it is difficult to control the morphology
    of a CP coating on the surface of carrier particles owing to the homogeneous nucleation
    of CP. In this study, we report the development of a CP-coating method that homogeneously
    corresponds to the shapes of silica–titania (SiTi) porous nanoparticles. We also
    demonstrate that controlled surface roughness of CP coatings could be achieved
    in SBF using SiTi nanoparticles with a well-defined spherical shape, a uniform
    size, and a tunable nanoporous structure. The precipitation of CP was performed
    on mono-dispersed porous SiTi nanoparticles with different Si/Ti molar ratios
    and pore sizes. The pore size distribution was found to significantly affect the
    CP coating in SBF immersion; the surfaces of the nanoparticles with bimodal pore
    sizes of 0.7 and 1.1–1.2 nm became rough after CP precipitation, while those with
    a unimodal pore size of 0.7 nm remained smooth, indicating that these two pore
    sizes serve as different nucleation sites that lead to different surface morphologies.
  description_type: abstract
  lang: eng

## Creator

- name: Reo Kimura
  role: author
  organization: Nagaoka University of Technology
- name: Kota Shiba
  role: author
  orcid: https://orcid.org/0000-0001-7775-0318
  organization: National Institute for Materials Science
  department: Research Center for Macromolecules and Biomaterials/Biomaterials Field/Olfactory
    Sensors Group
- name: Kanata Fujiwara
  role: author
  organization: Nagaoka University of Technology
- name: Yanni Zhou
  role: author
  organization: Nagaoka University of Technology
- name: Iori Yamada
  role: author
  organization: Nagaoka University of Technology
- name: Motohiro Tagaya
  role: author
  organization: Nagaoka University of Technology

## Contact agent



## Publisher

organization: Multidisciplinary Digital Publishing Institute (MDPI)

## Managing organization



## Keyword

- subject: bioceramic nanoparticles
  schema: not_defined
- subject: simulated body fluid
  schema: not_defined
- subject: nanopore
  schema: not_defined
- subject: CP precipitative coating
  schema: not_defined
- subject: silica–titania nanohybrid
  schema: not_defined

## Rights

- identifier: https://creativecommons.org/licenses/by/4.0/

## Other identifier(s)



## Data origin

- data_origin_type: other

## Embargo



## Journal

- title: Inorganics
  issn: '23046740'
  volume: '11'
  issue: '6'
  article_number: '235'

## Conference



## Related item



## Funding



## Instrument



## Instrument operator



## Instrument managing organization



## Measurement method



## Specimen



## Chemical composition



## Structure for specimen



## Structural feature for specimen



## Specific property for specimen



## Process for specimen treatment



## Computational method



## Energy level/transition state



## Software



## Custom property



## Fileset

- id: fe5ec3d6-8950-44f9-83e2-3ff0d7d203ef
  filename: inorganics-11-00235-v2.pdf
  content_type: application/pdf
  size: 4051507
  md5: 99840a240e14eeaa842714faabca842a
- id: 8528946f-dad8-4400-8107-97e8b21f4cb3
  filename: inorganics-11-00235-s001.zip
  content_type: application/zip
  size: 341507
  md5: 991c78f386a6842d45568bd324de5334

## Thumbnail

fileset_id: 8528946f-dad8-4400-8107-97e8b21f4cb3
filename: inorganics-11-00235-s001.zip