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Titania and silica have been recognized as potential drug delivery system (DDS) carriers. For this application, controllable biocompatibility and the suppression of the initial burst are required, which can be provided by a calcium phosphate (CP) coating. However, it is difficult to control the morphology of a CP coating on the surface of carrier particles owing to the homogeneous nucleation of CP. In this study, we report the development of a CP-coating method that homogeneously corresponds to the shapes of silica–titania (SiTi) porous nanoparticles. We also demonstrate that controlled surface roughness of CP coatings could be achieved in SBF using SiTi nanoparticles with a well-defined spherical shape, a uniform size, and a tunable nanoporous structure. The precipitation of CP was performed on mono-dispersed porous SiTi nanoparticles with different Si/Ti molar ratios and pore sizes. The pore size distribution was found to significantly affect the CP coating in SBF immersion; the surfaces of the nanoparticles with bimodal pore sizes of 0.7 and 1.1–1.2 nm became rough after CP precipitation, while those with a unimodal pore size of 0.7 nm remained smooth, indicating that these two pore sizes serve as different nucleation sites that lead to different surface morphologies.

権利情報:

• Creative Commons BY Attribution 4.0 International
  

キーワード: bioceramic nanoparticles, simulated body fluid, nanopore, CP precipitative coating, silica–titania nanohybrid

刊行年月日: 2023-05-28

出版者: Multidisciplinary Digital Publishing Institute (MDPI)

掲載誌:

• Inorganics (ISSN: 23046740) vol. 11 issue. 6 235

研究助成金:

原稿種別: 出版者版 (Version of record)

MDR DOI:

公開URL: https://doi.org/10.3390/inorganics11060235

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更新時刻: 2024-11-20 18:40:02 +0900

MDRでの公開時刻: 2024-11-20 18:40:02 +0900