# Elevation and adhesion properties of injectable hydrogels based on catechol/boronic acid-modified Alaska pollock gelatin for endoscopic submucosal dissection

https://mdr.nims.go.jp/datasets/c183d128-801c-4f06-bc30-1b8f0bb612f3

## File

- [Revised manuscript after acceptance_Colloid Surf B.docx](https://mdr.nims.go.jp/filesets/5ebee506-8d80-4832-8472-ca1d9e111d16/download) ([Detail](https://mdr.nims.go.jp/filesets/5ebee506-8d80-4832-8472-ca1d9e111d16.md))
- [Revised supporting information_Colloid Surf B.docx](https://mdr.nims.go.jp/filesets/15574597-e433-4c3f-bc22-bb1a91f952f6/download) ([Detail](https://mdr.nims.go.jp/filesets/15574597-e433-4c3f-bc22-bb1a91f952f6.md))

## Id

c183d128-801c-4f06-bc30-1b8f0bb612f3

## Local identifier



## Visibility

open_to_public

## State

published

## Created at

2024-10-16T05:44:30.085884Z

## Updated at

2024-10-17T05:38:07.372496Z

## Published at

2026-10-08T23:29:31.300021Z

## Doi

https://doi.org/10.48505/nims.4864

## First published url

https://doi.org/10.1016/j.colsurfb.2024.114307

## Date published

2024-10-09

## Recorded date published

2025-1

## Resource type

journal_article

## Manuscript type

accepted_manuscript

## Collection



## Title

- title: Elevation and adhesion properties of injectable hydrogels based on catechol/boronic
    acid-modified Alaska pollock gelatin for endoscopic submucosal dissection
  title_type: original
  lang: en

## Description

- description: Elevation of early-stage gastrointestinal cancer using submucosal injection
    materials (SIMs) and postoperative wound care with adhesive materials are crucial
    for preventing complications arising from endoscopic submucosal dissection (ESD).
    Several types of SIMs have been developed; however, they often provide insufficient
    tissue elevation and fail to adequately adhere to the defect following the removal
    of early-stage gastrointestinal cancer. In this study, we present the development
    of injectable Cat-PBA-ApGltn hydrogels, which are based on catechol group-modified
    Alaska pollock gelatin (Cat-ApGltn) and phenylboronic acid-modified Alaska pollock
    gelatin (PBA-ApGltn), serving as multifunctional SIMs. A Cat-ApGltn/PBA-ApGltn
    mixed solution formed a hydrogel within 3 seconds. The resulting Cat-PBA-ApGltn
    hydrogels were easily injected manually through a 23G needle due to their shear-thinning
    properties. Additionally, 10 w/v% Cat-PBA-ApGltn hydrogels demonstrated a 2.3-fold
    increase in mucosal elevation (7.2 ± 0.4 mm) compared with a commercially available
    SIM (3.1 ± 0.7 mm). The 10 w/v% Cat-PBA-ApGltn hydrogel, when adhered to porcine
    gastric submucosa, exhibited a burst strength 7 times greater than the average
    human intragastric pressure. Furthermore, the Cat-PBA-ApGltn hydrogels demonstrated
    biodegradability without inducing severe inflammation upon implantation in rat
    subcutaneous tissue. These Cat-PBA-ApGltn hydrogels hold promise as multifunctional
    SIMs, boasting injectability, excellent elevation, adhesion capabilities, and
    biodegradability.
  description_type: abstract
  lang: und

## Creator

- name: Kazuhiro Nagasaka
  role: author
- name: Hiyori Komatsu
  role: author
  orcid: https://orcid.org/0000-0002-2525-1362
- name: Shima Ito
  role: author
  orcid: https://orcid.org/0000-0002-3233-617X
- name: Debabrata Palai
  role: author
  orcid: https://orcid.org/0000-0003-1192-6143
- name: Akihiro Nishiguchi
  role: author
  orcid: https://orcid.org/0000-0002-3160-6385
- name: Tetsushi Taguchi
  role: author
  orcid: https://orcid.org/0000-0003-2541-2530

## Contact agent



## Publisher

organization: Elsevier BV

## Managing organization



## Keyword

- subject: Catechol-boronic acid interaction
  schema: not_defined
- subject: Endoscopic submucosal dissection
  schema: not_defined
- subject: Injectable hydrogel
  schema: not_defined
- subject: Tissue adhesive
  schema: not_defined

## Rights

- identifier: https://creativecommons.org/licenses/by-nc-nd/4.0/

## Other identifier(s)



## Data origin

- data_origin_type: other

## Embargo

start_date: 2024-10-09
end_date: 2026-10-09

## Journal

- title: 'Colloids and Surfaces B: Biointerfaces'
  issn: '09277765'
  volume: '245'
  article_number: '114307'

## Conference



## Related item



## Funding

- funder_name: Uehara Memorial Foundation
- identifier: 23H01718
  funder_name: Japan Society for the Promotion of Science
- identifier: 22K19947
  funder_name: Japan Society for the Promotion of Science
- identifier: 22H03962
  funder_name: Japan Society for the Promotion of Science

## Instrument



## Instrument operator



## Instrument managing organization



## Measurement method



## Specimen



## Chemical composition



## Structure for specimen



## Structural feature for specimen



## Specific property for specimen



## Process for specimen treatment



## Computational method



## Energy level/transition state



## Software



## Custom property



## Fileset

- id: 5ebee506-8d80-4832-8472-ca1d9e111d16
  filename: Revised manuscript after acceptance_Colloid Surf B.docx
  content_type: application/vnd.openxmlformats-officedocument.wordprocessingml.document
  size: 76195540
  md5: '09567d2eec3d27cff684467a4cf96cf8'
- id: 15574597-e433-4c3f-bc22-bb1a91f952f6
  filename: Revised supporting information_Colloid Surf B.docx
  content_type: application/vnd.openxmlformats-officedocument.wordprocessingml.document
  size: 25351049
  md5: b80473b9219c7a3b8ab3a76fc905b819

## Thumbnail

fileset_id: 5ebee506-8d80-4832-8472-ca1d9e111d16
filename: Revised manuscript after acceptance_Colloid Surf B.docx