# Synthetic Biomolecular Condensates: Phase‐Separation Control, Cytomimetic Modelling and Emerging Biomedical Potential

https://mdr.nims.go.jp/datasets/bf84dd3f-f1be-4780-96cf-e47bf3976e2b

## File

- [Angew Chem Int Ed - 2024 - Song - Synthetic Biomolecular Condensates  Phase‐Separation Control  Cytomimetic Modelling and.pdf](https://mdr.nims.go.jp/filesets/ab35c2a0-ad8e-4af5-bf37-44b4e19dde39/download) ([Detail](https://mdr.nims.go.jp/filesets/ab35c2a0-ad8e-4af5-bf37-44b4e19dde39.md))

## Id

bf84dd3f-f1be-4780-96cf-e47bf3976e2b

## Local identifier



## Visibility

open_to_public

## State

published

## Created at

2025-02-20T00:30:30.538038Z

## Updated at

2025-02-23T13:49:33.428248Z

## Published at

2025-02-23T13:49:33.522728Z

## Doi



## First published url

https://doi.org/10.1002/anie.202418431

## Date published

2025-02-17

## Recorded date published

2025-2-17

## Resource type

journal_article

## Manuscript type

vor

## Collection



## Title

- title: 'Synthetic Biomolecular Condensates: Phase‐Separation Control, Cytomimetic
    Modelling and Emerging Biomedical Potential'
  title_type: original
  lang: en

## Description

- description: Liquid-liquid phase separation towards the formation of synthetic coacervate
    droplets represents a rapidly advancing frontier in the fields of synthetic biology,
    material science, and biomedicine. These artificial constructures mimic the biophysical
    principles and dynamic features of natural biomolecular condensates that are pivotal
    for cellular regulation and organization. Via adapting biological concepts, synthetic
    condensates with dynamic phase-separation control provide crucial insights into
    the fundamental cell processes and regulation of complex biological pathways.
    They are increasingly designed with the ability to display more complex and ambitious
    cell-like features and behaviors, which offer innovative solutions for cytomimetic
    modeling and engineering active materials with sophisticated functions. In this
    minireview, we highlight recent advancements in the design and construction of
    synthetic coacervate droplets; including their biomimicry structure and organization
    to replicate life-like properties and behaviors, and the dynamic control towards
    engineering active coacervates. Moreover, we highlight the unique applications
    of synthetic coacervates as catalytic centers and promising delivery vehicles,
    so that these biomimicry assemblies can be translated into practical applications.
  description_type: abstract
  lang: und

## Creator

- name: Siyu Song
  role: author
- name: Tsvetomir Ivanov
  role: author
- name: Thao. P. Doan‐Nguyen
  role: author
- name: Lucas Caire da Silva
  role: author
- name: Jing Xie
  role: author
- name: Katharina Landfester
  role: author
- name: Shoupeng Cao
  role: author
  orcid: https://orcid.org/0000-0002-5856-2407
  organization: National Institute for Materials Science
  ror: https://ror.org/026v1ze26

## Contact agent



## Publisher

organization: Wiley

## Managing organization



## Keyword

- subject: biomimicry
  schema: not_defined
- subject: coacervate
  schema: not_defined
- subject: condensate
  schema: not_defined
- subject: liquid-liquid phase separation
  schema: not_defined
- subject: synthetic cell
  schema: not_defined

## Rights

- description: This is an open access article under the terms of the Creative Commons
    Attribution Non-Commercial License, which permits use, distribution and reproduction
    in any medium, provided the original work is properly cited and is not used for
    commercial purposes.
  identifier: https://creativecommons.org/licenses/by-nc/4.0/

## Other identifier(s)



## Data origin

- data_origin_type: other

## Embargo



## Journal

- title: Angewandte Chemie International Edition
  issn: '14337851'
  volume: '64'
  issue: '8'
  article_number: e202418431

## Conference



## Related item



## Funding

- identifier: '52403198'
  funder_name: National Natural Science Foundation of China
- identifier: '12302410'
  funder_name: National Natural Science Foundation of China
- identifier: 2024YFHZ0356
  funder_name: Sichuan Province Science and Technology Support Program
- funder_name: Fundamental Research Funds for the Central Universities
- funder_name: Federal Ministry of Education and Research of Germany (BMBF) and the
    Max Planck Society
  description: Max Planck Consortium for Synthetic Biology (MaxSynBio)
- funder_name: Projekt DEAL
  description: Open Access funding

## Instrument



## Instrument operator



## Instrument managing organization



## Measurement method



## Specimen



## Chemical composition



## Structure for specimen



## Structural feature for specimen



## Specific property for specimen



## Process for specimen treatment



## Computational method



## Energy level/transition state



## Software



## Custom property



## Fileset

- id: ab35c2a0-ad8e-4af5-bf37-44b4e19dde39
  filename: Angew Chem Int Ed - 2024 - Song - Synthetic Biomolecular Condensates  Phase‐Separation
    Control  Cytomimetic Modelling and.pdf
  content_type: application/pdf
  size: 14432516
  md5: 93f6c21d382637dec4cd420e72bdeff7

## Thumbnail

fileset_id: ab35c2a0-ad8e-4af5-bf37-44b4e19dde39
filename: Angew Chem Int Ed - 2024 - Song - Synthetic Biomolecular Condensates  Phase‐Separation
  Control  Cytomimetic Modelling and.pdf