# Metasurface Platform Incorporating Aggregation Induced Emission Based Biosensor for Enhanced Human Serum Albumin Detection

https://mdr.nims.go.jp/datasets/bc1d2a52-50fe-499f-9c87-f52dfe613188

## File

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## Id

bc1d2a52-50fe-499f-9c87-f52dfe613188

## Local identifier



## Visibility

open_to_public

## State

published

## Created at

2024-08-21T02:57:41.811892Z

## Updated at

2024-08-30T03:30:22.331196Z

## Published at

2024-08-30T03:30:22.909868Z

## Doi



## First published url

https://doi.org/10.1002/adom.202400868

## Date published

2024-06-04

## Recorded date published

2024-8

## Resource type

journal_article

## Manuscript type

vor

## Collection



## Title

- title: Metasurface Platform Incorporating Aggregation Induced Emission Based Biosensor
    for Enhanced Human Serum Albumin Detection
  title_type: original
  lang: en

## Description

- description: Metasurfaces exhibit excellent optical performance to enhance the light–matter
    interaction of target molecules in biosensing based on its well-optimized nanostructured
    unit cells. In the meantime, fluorescence (FL) biosensors with aggregation induced
    emissions (AIE) features also demonstrate outstanding performance in biomarker
    detection due to its fast response, high selectivity, and low background noise.
    Nevertheless, extremely low-level analytes are difficult to detect in practical
    applications since complex urine samples include a number of uncontrolled variables
    such as impurities, autofluorescence, other urine components, etc. At present,
    improving photosignal sensitivity of human serum albumin (HSA) detection is always
    a big challenge to overcome such interference in human urine scenarios.  In this
    work, we have first combined an AIE-based fluorescent FL biosensor TPE-4TA with
    an all-dielectric metasurface platform to achieve quantitative detection of trace
    HSA in urine by utilizing biofunctionalization protocols on the silicon nanostructures.
    The results indicate significant FL enhancement in metasurface platform that offers
    a promising pathway for improving biomarker detection in the future.
  description_type: abstract
  lang: und

## Creator

- name: Qi Hu
  role: author
- name: Masanobu Iwanaga
  role: author
  orcid: https://orcid.org/0000-0002-8930-6940
  organization: National Institute for Materials Science
- name: Youhong Tang
  role: author

## Contact agent



## Publisher

organization: Wiley

## Managing organization



## Keyword

- subject: Metasurface platform
  schema: not_defined
- subject: AIE FL biosensors
  schema: not_defined
- subject: HSA detection
  schema: not_defined
- subject: Mult-level immobilizations
  schema: not_defined
- subject: Si nanocolumns
  schema: not_defined

## Rights

- identifier: https://creativecommons.org/licenses/by/4.0/

## Other identifier(s)



## Data origin

- data_origin_type: other

## Embargo



## Journal

- title: Advanced Optical Materials
  issn: '21951071'
  volume: '12'
  issue: '23'
  article_number: '2400868'

## Conference



## Related item



## Funding

- identifier: JPMXP1223NM5163
  funder_name: Ministry of Education, Culture, Sports, Science and Technology

## Instrument



## Instrument operator



## Instrument managing organization



## Measurement method



## Specimen



## Chemical composition



## Structure for specimen



## Structural feature for specimen



## Specific property for specimen



## Process for specimen treatment



## Computational method



## Energy level/transition state



## Software



## Custom property



## Fileset

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  filename: adom202400868-sup-0001-suppmat.docx
  content_type: application/vnd.openxmlformats-officedocument.wordprocessingml.document
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- id: e579dfa3-c891-4d72-8de5-2a907d7be920
  filename: Advanced Optical Materials 12(2024)2400868 - Hu - Iwanaga - Tang - Metasurface
    Platform Incorporating AIE.pdf
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  size: 2544954
  md5: 82f5c13b667b912b01b7cfbb209bbf79

## Thumbnail

fileset_id: 7c7e3400-29f3-46b1-a076-fc666b872e2b
filename: adom202400868-sup-0001-suppmat.docx