# Geometrically engineered organoid units and their assembly for pre-construction of organ structures

https://mdr.nims.go.jp/datasets/bbc54f14-cf36-4104-a74e-0b360f690523

## File

- [046112_1_5.0222866.pdf](https://mdr.nims.go.jp/filesets/00bc12fb-8ef8-42bd-bc5a-7a21fe912450/download) ([Detail](https://mdr.nims.go.jp/filesets/00bc12fb-8ef8-42bd-bc5a-7a21fe912450.md))

## Id

bbc54f14-cf36-4104-a74e-0b360f690523

## Local identifier



## Visibility

open_to_public

## State

published

## Created at

2024-11-27T00:47:01.049843Z

## Updated at

2024-12-03T07:31:14.959451Z

## Published at

2024-12-03T07:31:15.048649Z

## Doi



## First published url

https://doi.org/10.1063/5.0222866

## Date published

2024-12-01

## Recorded date published

2024-12-1

## Resource type

journal_article

## Manuscript type

vor

## Collection



## Title

- title: Geometrically engineered organoid units and their assembly for pre-construction
    of organ structures
  title_type: original
  lang: en

## Description

- description: 細胞の種類や細胞外マトリックス、接着成分に依存しない様々な形状のオルガノイドユニットの作製、連結、組み立て方法（ユニット構築法）を確立した。また、ヒトの腎臓を構成する3種類の実質細胞と間質細胞を用いて腎組織様構造を作製し、ユニット間のクロストークの可能性を示唆する知見を得た。
  description_type: abstract
  lang: eng
- description: We established a method for fabricating, connecting, and assembling
    organoid units of various shapes independent of cell type, extracellular matrix,
    and adhesive composition (unit construction method). We also fabricated kidney
    tissue-like structures using three types of parenchymal and interstitial cells
    that compose the human kidney and obtained findings suggesting the possibility
    of crosstalk between the units.
  description_type: abstract
  lang: en

## Creator

- name: Ayaka Kadotani
  role: author
- name: Gen Hayase
  role: author
  orcid: https://orcid.org/0000-0003-1970-6129
  organization: National Institute for Materials Science
  ror: https://ror.org/026v1ze26
- name: Daisuke Yoshino
  role: author

## Contact agent



## Publisher

organization: AIP Publishing

## Managing organization



## Keyword

- subject: tissue engineering
  schema: not_defined
- subject: superhydrophobic substrate
  schema: not_defined
- subject: organoid
  schema: not_defined
- subject: unit construction method
  schema: not_defined

## Rights

- identifier: https://creativecommons.org/licenses/by-nc-nd/4.0/

## Other identifier(s)



## Data origin

- data_origin_type: other

## Embargo



## Journal

- title: APL Bioengineering
  issn: '24732877'
  volume: '8'
  issue: '4'
  article_number: '046112'

## Conference



## Related item



## Funding

- identifier: 21K19893
  funder_name: Japan Society for the Promotion of Science
- identifier: JPMJFR222S
  funder_name: Japan Science and Technology Agency
- identifier: 2023-097
  funder_name: National Institute for Materials Science

## Instrument



## Instrument operator



## Instrument managing organization



## Measurement method



## Specimen



## Chemical composition



## Structure for specimen



## Structural feature for specimen



## Specific property for specimen



## Process for specimen treatment



## Computational method



## Energy level/transition state



## Software



## Custom property



## Fileset

- id: 00bc12fb-8ef8-42bd-bc5a-7a21fe912450
  filename: 046112_1_5.0222866.pdf
  content_type: application/pdf
  size: 4714259
  md5: ed52c4d1b4fd6e7063457644087bf11b

## Thumbnail

fileset_id: 00bc12fb-8ef8-42bd-bc5a-7a21fe912450
filename: 046112_1_5.0222866.pdf