# Anti-hepatocellular carcinoma activities of novel hydrazone derivatives <i>via</i> downregulation of interleukin-6

https://mdr.nims.go.jp/datasets/bb2abfe7-4de0-4583-bca8-77e392a95076

## File

- [d4ra05854b (2).pdf](https://mdr.nims.go.jp/filesets/8fffd296-3bd3-48bb-826a-a513a24b55f7/download) ([Detail](https://mdr.nims.go.jp/filesets/8fffd296-3bd3-48bb-826a-a513a24b55f7.md))

## Id

bb2abfe7-4de0-4583-bca8-77e392a95076

## Local identifier



## Visibility

open_to_public

## State

published

## Created at

2024-12-02T03:36:45.799354Z

## Updated at

2024-12-04T05:53:06.673601Z

## Published at

2024-12-04T05:53:06.744728Z

## Doi



## First published url

https://doi.org/10.1039/d4ra05854b

## Date published

2024-11-28

## Recorded date published

2024-11-25

## Resource type

journal_article

## Manuscript type

vor

## Collection



## Title

- title: Anti-hepatocellular carcinoma activities of novel hydrazone derivatives <i>via</i>
    downregulation of interleukin-6
  title_type: original
  lang: en

## Description

- description: "Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related
    morbidity\r\nworldwide. Sorafenib is a first-line drug for the treatment of HCC,
    however, it is reported to\r\ncause serious adverse effects and may lead to resistance
    in many patients. In this study, 20\r\nhydrazone derivatives incorporating triazoles,
    pyrazolone, pyrrole, pyrrolidine, imidazoline,\r\nquinazoline, and oxadiazine
    moieties were designed, synthesized, and characterized. In\r\naddition to molecular
    docking and in silico ADME study, the cytotoxic activity of the\r\nsynthesized
    compounds was evaluated against the human hepatocellular cancer cell line\r\n(HepG2)
    and liver mesenchymal stem cells as a normal cell line. The antitumor activities
    of\r\nthe derivatives against sorafenib were compared. Of the 20 synthesized compounds,\r\ncompound
    16 demonstrated potential as a potent anti-HCC drug candidate through\r\ndownregulation
    of interleukin 6 which reduces inflammation and tumorigenesis with a strong\r\nbinding
    interaction and bioavailability.\r\n"
  description_type: abstract
  lang: und

## Creator

- name: Ahmed Nabil
  role: author
  orcid: https://orcid.org/0000-0002-5617-4726
- name: Marwa Abdel-Motaal
  role: author
- name: Ayman Hassan
  role: author
- name: Mohamed M. Elshemy
  role: author
- name: Medhat Asem
  role: author
- name: Mariam Elwan
  role: author
- name: Mitsuhiro Ebara
  role: author
  orcid: https://orcid.org/0000-0002-7906-0350
  organization: National Institute for Materials Science
- name: Mohammed Abdelmageed
  role: author
- name: Gamal Shiha
  role: author
- name: Hassan M. E. Azzazy
  role: author

## Contact agent



## Publisher

organization: Royal Society of Chemistry (RSC)

## Managing organization



## Keyword

- subject: HCC, IL-6, hydrazone derivatives, antitumor, cytochrome c, molecular docking
    simulation, Sorafenib, 5-fluoruracil, hepatocellular carcinoma.
  schema: not_defined

## Rights

- identifier: cc-by-3.0

## Other identifier(s)



## Data origin

- data_origin_type: other

## Embargo



## Journal

- title: RSC Advances
  issn: '20462069'
  volume: '14'
  issue: '51'
  start_page: 37960
  end_page: 37974

## Conference



## Related item



## Funding

- funder_name: American University in Cairo

## Instrument



## Instrument operator



## Instrument managing organization



## Measurement method



## Specimen



## Chemical composition



## Structure for specimen



## Structural feature for specimen



## Specific property for specimen



## Process for specimen treatment



## Computational method



## Energy level/transition state



## Software



## Custom property



## Fileset

- id: 8fffd296-3bd3-48bb-826a-a513a24b55f7
  filename: d4ra05854b (2).pdf
  content_type: application/pdf
  size: 2339243
  md5: c28f44969072dd5ca055be177ac284f8

## Thumbnail

fileset_id: 8fffd296-3bd3-48bb-826a-a513a24b55f7
filename: d4ra05854b (2).pdf