# Micropore-forming photocurable tissue adhesive promotes cell infiltration for wound healing

https://mdr.nims.go.jp/datasets/b9397201-48ee-4555-8c54-5f5f1d5b5944

## Files

- [Manuscript-R.docx](https://mdr.nims.go.jp/filesets/68a5a4fc-cbc0-41ce-ae72-8be477c02632/download) ([Detail](https://mdr.nims.go.jp/filesets/68a5a4fc-cbc0-41ce-ae72-8be477c02632.md))

## Id

b9397201-48ee-4555-8c54-5f5f1d5b5944

## Local identifier



## Visibility

open_to_public

## State

published

## Created at

2025-10-27T04:57:44.681111Z

## Updated at

2025-12-09T07:30:48.031252Z

## Published at

2025-12-09T07:26:06.603648Z

## Doi

https://doi.org/10.48505/nims.5974

## First published url

https://doi.org/10.1016/j.actbio.2025.09.033

## Date published

2025-09-25

## Recorded date published

2025-10

## Resource type

journal_article

## Manuscript type

authors_original

## Collection



## Title

- title: Micropore-forming photocurable tissue adhesive promotes cell infiltration
    for wound healing
  title_type: original
  lang: en

## Description

- description: Tissue adhesives suffer from a trade-off relationship between tissue
    adhesion strength for long-term wound closure and degradation rate for tissue
    regeneration, which results in the suppression of postoperative wound healing.
    Here, we report the development of micropore-forming tissue adhesives with an
    enhanced cell infiltration capacity for tissue regeneration. By leveraging the
    phase-separation behavior of gelatin modified with hydrogen-bonding moieties,
    bicontinuous and micropore-forming photocrosslinked hydrogels were developed.
    The photocrosslinked hydrogels are injectable and enzymatically degradable, showing
    high tissue adhesive strength against tissues of the collagen membrane, heart,
    stomach, and large intestine. Moreover, the microporous structure of the hydrogels
    could enhance fibroblast infiltration through the micropores. These hydrogels
    could also induce hair follicle regeneration and wound healing in skin incision
    wound models. This tissue adhesive has enormous potential for promoting wound
    healing and preventing postoperative complications.
  description_type: abstract
  lang: und

## Creator

- name: Akihiro Nishiguchi
  role: author
  orcid: https://orcid.org/0000-0002-3160-6385
  organization: National Institute for Materials Science
- name: Miho Ohta
  role: author
- name: Debabrata Palai
  role: author
  orcid: https://orcid.org/0000-0003-1192-6143
  organization: National Institute for Materials Science
- name: Hana Yasue
  role: author
  organization: National Institute for Materials Science
- name: Pritha Sarkar
  role: author
- name: Hiyori Komatsu
  role: author
  orcid: https://orcid.org/0000-0002-2525-1362
  organization: National Institute for Materials Science
- name: Tetsushi Taguchi
  role: author
  orcid: https://orcid.org/0000-0003-2541-2530
  organization: National Institute for Materials Science

## Contact agent



## Publisher

organization: Elsevier BV

## Managing organization



## Keyword

- subject: Hydrogel
  schema: not_defined

## Rights

- identifier: http://rightsstatements.org/vocab/InC/1.0/

## Other identifier(s)



## Data origin

- data_origin_type: other

## Embargo



## Journal

- title: Acta Biomaterialia
  issn: '17427061'
  volume: '206'
  start_page: 215
  end_page: 224

## Conference



## Related item



## Funding

- identifier: 22H03962
  funder_name: Japan Society for the Promotion of Science
- funder_name: Inamori Foundation
- funder_name: Toshiaki Ogasawara Memorial Foundation
- funder_name: Japan Agency for Medical Research and Development
- funder_name: Uehara Memorial Foundation

## Instrument



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## Instrument managing organization



## Measurement method



## Specimen



## Chemical composition



## Structure for specimen



## Structural feature for specimen



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## Fileset

- id: 68a5a4fc-cbc0-41ce-ae72-8be477c02632
  filename: Manuscript-R.docx
  content_type: application/vnd.openxmlformats-officedocument.wordprocessingml.document
  size: 5694531
  md5: 2157467b87d7ffc9796576c7b2e8d378

## Thumbnail

fileset_id: 68a5a4fc-cbc0-41ce-ae72-8be477c02632
filename: Manuscript-R.docx