# G-Quadruplex Structure Improves the Immunostimulatory Effects of CpG Oligonucleotides

https://mdr.nims.go.jp/datasets/b4236040-80df-48f6-9971-3678cf8d49a1

## File

- [NAT-2018-0761_Manuscript2.pdf](https://mdr.nims.go.jp/filesets/83cfc74e-ef58-40b3-b0bd-e83d71878d02/download) ([Detail](https://mdr.nims.go.jp/filesets/83cfc74e-ef58-40b3-b0bd-e83d71878d02.md))

## Id

b4236040-80df-48f6-9971-3678cf8d49a1

## Local identifier



## Visibility

open_to_public

## State

published

## Created at

2021-08-05T16:24:06.328523Z

## Updated at

2024-01-05T13:13:10.366902Z

## Published at

2021-08-12T16:20:03.393787Z

## Doi

https://doi.org/10.48505/nims.1443

## First published url

https://doi.org/10.1089/nat.2018.0761

## Date published

2019-03-05

## Recorded date published

2019-8

## Resource type

journal_article

## Manuscript type

authors_original

## Collection



## Title

- title: G-Quadruplex Structure Improves the Immunostimulatory Effects of CpG Oligonucleotides
  title_type: original
  lang: en

## Description

- description: Single-strand oligodeoxynucleotides (ODNs) containing unmethylated
    cytosine-phosphate-guanine (CpG) are recognized by the toll-like receptor 9, a
    component of the innate immunity. Therefore, they could act as immunotherapeutic
    agents. Chemically modified CpG ODNs containing a phosphorothioate backbone instead
    of phosphodiester (PD) were developed as immunotherapeutic agents resistant to
    nuclease degradation. However, they cause adverse side effects, and so there is
    a necessity to generate novel CpG ODNs. In the present study, we designed a nuclease-resistant
    nonmodified CpG ODN that forms G-quadruplex structures. G-quadruplex formation
    in CpG ODNs increased nuclease resistance and cellular uptake. The CpG ODNs designed
    in this study induced interleukin-6 production in a human B lymphocyte cell line
    and human peripheral blood mononuclear cells. These results indicate that G-quadruplex
    formation can be used to increase the immunostimulatory activity of CpG ODNs having
    a natural PD backbone.
  description_type: abstract
  lang: en

## Creator

- name: Hoshi, Kazuaki
  role: author
- name: Yamazaki, Tomohiko
  role: author
  orcid: https://orcid.org/0000-0003-2136-8042
- name: Sugiyama, Yuuki
  role: author
- name: Tsukakoshi, Kaori
  role: author
- name: Tsugawa, Wakako
  role: author
- name: Sode, Koji
  role: author
- name: Ikebukuro, Kazunori
  role: author

## Contact agent



## Publisher

organization: Mary Ann Liebert

## Managing organization



## Keyword

- subject: IL-6
  schema: not_defined
- subject: toll-like receptor 9
  schema: not_defined
- subject: CpG ODN
  schema: not_defined
- subject: G-quadruplex
  schema: not_defined
- subject: peripheral blood mononuclear cells
  schema: not_defined

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## Fileset

- id: 83cfc74e-ef58-40b3-b0bd-e83d71878d02
  filename: NAT-2018-0761_Manuscript2.pdf
  content_type: application/pdf
  size: 457887
  md5: d3e8cf0f21bd8e64d3479cb49477c373

## Thumbnail

fileset_id: 83cfc74e-ef58-40b3-b0bd-e83d71878d02
filename: NAT-2018-0761_Manuscript2.pdf