# Thermosensitive liposomal nanomedicine-functionalized photothermal composite scaffolds for light-guided cancer therapy

https://mdr.nims.go.jp/datasets/adbf5fb2-bae0-4c87-a5e7-99ba9ad7f309

## File

- [Xiaohan Liu_accepted manuscript.pdf](https://mdr.nims.go.jp/filesets/c3d5b8f6-0ca3-4a8f-9d94-caf9bffb8508/download) ([Detail](https://mdr.nims.go.jp/filesets/c3d5b8f6-0ca3-4a8f-9d94-caf9bffb8508.md))

## Id

adbf5fb2-bae0-4c87-a5e7-99ba9ad7f309

## Local identifier



## Visibility

open_to_public

## State

published

## Created at

2025-10-14T00:50:59.112682Z

## Updated at

2025-10-14T08:18:53.518999Z

## Published at

2026-07-10T23:24:31.427845Z

## Doi

https://doi.org/10.48505/nims.5808

## First published url

https://doi.org/10.1039/d5mh00888c

## Date published

2025-07-11

## Recorded date published

2025-10-13

## Resource type

journal_article

## Manuscript type

accepted_manuscript

## Collection



## Title

- title: Thermosensitive liposomal nanomedicine-functionalized photothermal composite
    scaffolds for light-guided cancer therapy
  title_type: original
  lang: en

## Description

- description: In this study, a novel implantable in situ therapeutic composite scaffold
    platform (ALA@lipo/Au/Gel/PGA) was developed based on a porous scaffold composed
    of biocompatible gelatin and polyglutamic acid (PGA). This platform incorporated
    the photothermal agent Au nanorods (AuNRs) and thermosensitive liposomes encapsulated
    with the photosensitizer precursor 5-aminolevulinic acid (ALA). Due to the satisfactory
    photothermal conversion effect of the ALA@lipo/Au/Gel/PGA composite scaffold,
    the use of near-infrared (NIR) light not only ablated the cancer cells in the
    scaffold through photothermal therapy (PTT) but also induced the accelerated release
    of encapsulated ALA from the thermosensitive liposomes. After uptake, ALA could
    generate cytotoxic reactive oxygen species to increase tumour cell elimination
    efficiency via photodynamic therapy (PDT). Both in vitro and in vivo experiments
    demonstrated the synergistic anticancer effects of the composite scaffold.
  description_type: abstract
  lang: und

## Creator

- name: Xiaohan Liu
  role: author
  orcid: https://orcid.org/0009-0004-6486-0779
- name: Huajian Chen
  role: author
  orcid: https://orcid.org/0000-0003-1643-9782
- name: Man Wang
  role: author
- name: Tianjiao Zeng
  role: author
  orcid: https://orcid.org/0000-0002-1286-0337
- name: Toru Yoshitomi
  role: author
  orcid: https://orcid.org/0000-0003-3847-1812
- name: Naoki Kawazoe
  role: author
  orcid: https://orcid.org/0000-0003-3916-0709
- name: Yingnan Yang
  role: author
- name: Guoping Chen
  role: author
  orcid: https://orcid.org/0000-0001-6753-3678

## Contact agent



## Publisher

organization: Royal Society of Chemistry (RSC)

## Managing organization



## Keyword

- subject: thermosensitive liposome
  schema: not_defined
- subject: nanomedicine
  schema: not_defined
- subject: photothermal
  schema: not_defined
- subject: composite scaffolds
  schema: not_defined
- subject: cancer therapy
  schema: not_defined

## Rights

- identifier: http://rightsstatements.org/vocab/InC/1.0/

## Other identifier(s)



## Data origin

- data_origin_type: other

## Embargo

start_date: 2025-07-11
end_date: 2026-07-11

## Journal

- title: Materials Horizons
  issn: '20516347'
  volume: '12'
  issue: '20'
  start_page: 8654
  end_page: 8666

## Conference



## Related item



## Funding

- identifier: 19H04475
  funder_name: Japan Society for the Promotion of Science
- identifier: 24K03289
  funder_name: Japan Society for the Promotion of Science

## Instrument



## Instrument operator



## Instrument managing organization



## Measurement method



## Specimen



## Chemical composition



## Structure for specimen



## Structural feature for specimen



## Specific property for specimen



## Process for specimen treatment



## Computational method



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## Fileset

- id: c3d5b8f6-0ca3-4a8f-9d94-caf9bffb8508
  filename: Xiaohan Liu_accepted manuscript.pdf
  content_type: application/pdf
  size: 3677579
  md5: eb2cd7609b21de023c03c780a43177d7

## Thumbnail

fileset_id: c3d5b8f6-0ca3-4a8f-9d94-caf9bffb8508
filename: Xiaohan Liu_accepted manuscript.pdf