Long-term exposure in high viscous microenvironment facilitates acquired drug resistance of colon cancer cells to doxorubicin

Tianjiao Zeng; Chengyu Lu; Man Wang; Huajian Chen; Toru Yoshitomi; Naoki Kawazoe; Yingnan Yang; Guoping Chen

doi:10.1016/j.ejpb.2025.114852

ジャーナル論文 Long-term exposure in high viscous microenvironment facilitates acquired drug resistance of colon cancer cells to doxorubicin

; ; ; ;

;

; ;

Download file (3MB)
Download as zip (2.8MB)

コレクション

引用

Tianjiao Zeng, Chengyu Lu, Man Wang, Huajian Chen, Toru Yoshitomi, Naoki Kawazoe, Yingnan Yang, Guoping Chen. Long-term exposure in high viscous microenvironment facilitates acquired drug resistance of colon cancer cells to doxorubicin. European Journal of Pharmaceutics and Biopharmaceutics. 2025, 216 (), 114852. https://doi.org/10.1016/j.ejpb.2025.114852

(BibTeX)

説明:

(abstract)

In this study, the effect of microenvironmental viscosity on ADR of colon cancer cells to doxorubicin (DOX) was investigated by long-term culture of colon cancer cells in different viscous media supplemented with DOX. The 50% inhibitory concentration (IC50) value of drug-resistant cells established by culturing in high viscosity media was significantly higher than that of cells cultured in low viscosity media. The drug-resistant colon cancer cells established in high viscosity media exhibited higher expression levels of drug resistance-related genes (ABCC2 and ABCG2), higher migration ability and lower proliferation ability than the cells established in low viscosity medium. Long-term exposure in DOX-containing high viscosity media made the cells more tolerant to DOX and facilitated the ADR of colon cancer cells to DOX.

権利情報: