# Control of Corrosion Resistance and Osteoclastic Resorbability of Bioresorbable Carbonate Apatite Coating for Biodegradable Mg Alloys through Carbonate Content

https://mdr.nims.go.jp/datasets/aac01f0a-2326-46ce-9713-734236815681

## File

- [manuscript ACS biomater sci eng MDR.pdf](https://mdr.nims.go.jp/filesets/62a7f7aa-9532-4cb0-a02a-1de4c80d54c0/download) ([Detail](https://mdr.nims.go.jp/filesets/62a7f7aa-9532-4cb0-a02a-1de4c80d54c0.md))
- [Suppl mater 20251105 submit.pdf](https://mdr.nims.go.jp/filesets/2999727e-a072-4858-b2a0-b2c201c8b72e/download) ([Detail](https://mdr.nims.go.jp/filesets/2999727e-a072-4858-b2a0-b2c201c8b72e.md))

## Id

aac01f0a-2326-46ce-9713-734236815681

## Local identifier



## Visibility

open_to_public

## State

published

## Created at

2026-01-19T00:34:32.738939Z

## Updated at

2026-01-19T01:10:38.824869Z

## Published at

2026-01-19T03:21:46.077428Z

## Doi

https://doi.org/10.48505/nims.6142

## First published url

https://doi.org/10.1021/acsbiomaterials.5c01706

## Date published

2026-01-12

## Recorded date published

2026-1-12

## Resource type

journal_article

## Manuscript type

accepted_manuscript

## Collection



## Title

- title: Control of Corrosion Resistance and Osteoclastic Resorbability of Bioresorbable
    Carbonate Apatite Coating for Biodegradable Mg Alloys through Carbonate Content
  title_type: original
  lang: en

## Description

- description: "ABSTRACT\r\nTo investigate the effect of carbonate content on the
    corrosion resistance and osteoclastic resorbability of carbonate apatite (CAp)
    coatings for biodegradable Mg alloys, polarization, electrochemical impedance
    (EI), and osteoclast precursor cell culture tests were conducted for CAp-coated
    pure Mg (Mg) and Mg-4Y-3RE (WE43) containing approximately 11, 17, and 18 wt%
    carbonate. In Hanks’ solution, the polarization resistance (Rp) was higher than
    in 0.9% NaCl solution, and the CAp coatings improved the Rp of Mg by 7 to 15 times.
    The Rp of CAp-coated Mg increased by approximately 1.5 times in 0.9% NaCl solution
    and 2 times in Hanks’ solution with increasing carbonate content, indicating a
    reduction in coating defects. For CAp-coated Mg, osteoclasts only survived on
    higher carbonate content coating. For WE43, the coating with higher carbonate
    content exhibited a higher number of mature osteoclasts and approximately a 1.5-fold
    increase in the resorbed area by osteoclasts. These findings demonstrate that
    the carbonate content in the CAp coating allows for the adjustment of the corrosion
    rate of biodegradable Mg alloys to suit the affected part of the body. It was
    also found that once osteoclasts are induced, the CAp coating with higher carbonate
    content is resorbed more quickly by the osteoclasts."
  description_type: abstract
  lang: und

## Creator

- name: Sachiko Hiromoto
  role: author
  orcid: https://orcid.org/0000-0003-4666-6708
- name: Kazuma Midorikawa
  role: author
- name: Tomohiko Yamazaki
  role: author
  orcid: https://orcid.org/0000-0003-2136-8042
- name: Tomoyuki Yamamoto
  role: author
  orcid: https://orcid.org/0000-0002-9932-4368

## Contact agent



## Publisher

organization: American Chemical Society (ACS)

## Managing organization



## Keyword

- subject: carbonate apatite coating
  schema: not_defined
- subject: carbonate content
  schema: not_defined
- subject: corrosion
  schema: not_defined
- subject: bioabsorption
  schema: not_defined
- subject: biomedical magnesium alloys
  schema: not_defined
- subject: calcium phosphate
  schema: not_defined

## Rights

- identifier: https://creativecommons.org/licenses/by/4.0/

## Other identifier(s)



## Data origin



## Embargo



## Journal

- title: ACS Biomaterials Science & Engineering
  issn: '23739878'
  volume: '12'
  issue: '1'
  start_page: 322
  end_page: 334

## Conference



## Related item



## Funding

- identifier: JPMXP1224NM5085
  funder_name: Ministry of Education, Culture, Sports, Science and Technology
- identifier: 23K23066
  funder_name: Japan Society for the Promotion of Science

## Instrument



## Instrument operator



## Instrument managing organization



## Measurement method



## Specimen



## Chemical composition



## Structure for specimen



## Structural feature for specimen



## Specific property for specimen



## Process for specimen treatment



## Computational method



## Energy level/transition state



## Software



## Custom property



## Fileset

- id: 62a7f7aa-9532-4cb0-a02a-1de4c80d54c0
  filename: manuscript ACS biomater sci eng MDR.pdf
  content_type: application/pdf
  size: 4192100
  md5: 77b67fc9757c03471bab2645c9c0c7f4
- id: 2999727e-a072-4858-b2a0-b2c201c8b72e
  filename: Suppl mater 20251105 submit.pdf
  content_type: application/pdf
  size: 2312383
  md5: c72a46c627d2da4a4bdf99012c360983

## Thumbnail

fileset_id: 62a7f7aa-9532-4cb0-a02a-1de4c80d54c0
filename: manuscript ACS biomater sci eng MDR.pdf