# A Heparin‐Functionalized Scaffold with HB‐EGF Immobilization for Tissue Engineering

https://mdr.nims.go.jp/datasets/aa2c825b-af8b-42b3-9883-b1dafa1c982e

## File

- [Adv Healthcare Materials - 2025 - Peng - A Heparin‐Functionalized Scaffold with HB‐EGF Immobilization for Tissue.pdf](https://mdr.nims.go.jp/filesets/dcf7f353-0d36-4552-bd6f-ea242ea721e4/download) ([Detail](https://mdr.nims.go.jp/filesets/dcf7f353-0d36-4552-bd6f-ea242ea721e4.md))

## Id

aa2c825b-af8b-42b3-9883-b1dafa1c982e

## Local identifier



## Visibility

open_to_public

## State

published

## Created at

2025-10-14T00:36:49.104151Z

## Updated at

2025-10-21T07:06:17.866623Z

## Published at

2025-10-21T06:43:25.517495Z

## Doi



## First published url

https://doi.org/10.1002/adhm.202502771

## Date published

2025-10-01

## Recorded date published



## Resource type

journal_article

## Manuscript type

vor

## Collection



## Title

- title: A Heparin‐Functionalized Scaffold with HB‐EGF Immobilization for Tissue Engineering
  title_type: original
  lang: en

## Description

- description: In this study, a heparin-functionalized scaffold is designed to mimic
    the GFs reservoir function of extracellular matrix (ECM). Owing to its heparin-binding
    domain, heparin-binding epidermal growth factor-like growth factor (HB-EGF) is
    effectively and spatially captured by heparin-functionalized scaffold. Furthermore,
    the strong interaction between heparin and heparin-binding domain confers excellent
    stability of the immobilized HB-EGF in scaffold over a long period. The heparin-functionalized
    scaffold immobilized with HB-EGF facilitates cell adhesion and promotes proliferation
    of human mesenchymal stem cells (hMSCs), while not inducing their differentiation
    during proliferation.
  description_type: abstract
  lang: und

## Creator

- name: Bowu Peng
  role: author
- name: Huajian Chen
  role: author
- name: Chengyu Lu
  role: author
- name: Tianjiao Zeng
  role: author
  orcid: https://orcid.org/0000-0002-1286-0337
- name: Man Wang
  role: author
- name: Toru Yoshitomi
  role: author
  orcid: https://orcid.org/0000-0003-3847-1812
- name: Naoki Kawazoe
  role: author
  orcid: https://orcid.org/0000-0003-3916-0709
- name: Yingnan Yang
  role: author
- name: Guoping Chen
  role: author
  orcid: https://orcid.org/0000-0001-6753-3678

## Contact agent



## Publisher

organization: Wiley

## Managing organization



## Keyword

- subject: HB-EGF
  schema: not_defined
- subject: heparin
  schema: not_defined
- subject: hMSCs
  schema: not_defined
- subject: immobilization
  schema: not_defined
- subject: porous scaffold
  schema: not_defined
- subject: tissue engineering
  schema: not_defined

## Rights

- identifier: https://creativecommons.org/licenses/by-nc/4.0/

## Other identifier(s)



## Data origin

- data_origin_type: other

## Embargo



## Journal

- title: Advanced Healthcare Materials
  issn: '21922640'
  article_number: e02771

## Conference



## Related item



## Funding

- identifier: JPMJSP2124
  funder_name: Japan Science and Technology Agency
- identifier: 24K03289
  funder_name: Japan Society for the Promotion of Science

## Instrument



## Instrument operator



## Instrument managing organization



## Measurement method



## Specimen



## Chemical composition



## Structure for specimen



## Structural feature for specimen



## Specific property for specimen



## Process for specimen treatment



## Computational method



## Energy level/transition state



## Software



## Custom property



## Fileset

- id: dcf7f353-0d36-4552-bd6f-ea242ea721e4
  filename: Adv Healthcare Materials - 2025 - Peng - A Heparin‐Functionalized Scaffold
    with HB‐EGF Immobilization for Tissue.pdf
  content_type: application/pdf
  size: 4338158
  md5: 6429c43f7217abf376d8a7200007c16f

## Thumbnail

fileset_id: dcf7f353-0d36-4552-bd6f-ea242ea721e4
filename: Adv Healthcare Materials - 2025 - Peng - A Heparin‐Functionalized Scaffold
  with HB‐EGF Immobilization for Tissue.pdf