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Description:

ゾル－ゲル法で作製したナノファイバー強化骨格をもつポリメチルシルセスキオキサン多孔体をCNCミリングによりmm以下の精度で加工し、撥水基板を作製した。この材料を利用して三次元培養を行うことで数mm大の球状スフェロイドを高効率で形成できた。

Description:

Polymethylsilsesquioxane macroporous monoliths with a nanofiber-reinforced framework, fabricated using the sol-gel method, was machined with sub-millimeter precision using CNC milling to produce a hydrophobic substrate. The use of this material for three-dimensional cell culture enabled the efficient formation of spherical spheroids several millimeters in size.

Rights:

• In Copyright
  This document is the Accepted Manuscript version of a Published Work that appeared in final form in ACS Applied Bio Materials, copyright © 2020 American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://doi.org/10.1021/acsabm.0c00719

Keyword: porous monoliths, sol-gel, silsesquioxane, nanofibers, hydrophobicity, micromilling, 3d cell culture

Date published: 2020-08-17

Publisher: American Chemical Society (ACS)

Journal:

• ACS Applied Bio Materials (ISSN: 25766422) vol. 3 issue. 8 p. 4747-4750

Funding:

• Takeda Science Foundation
• Ministry of Education, Culture, Sports, Science and Technology
• Japan Society for the Promotion of Science 17K14541

Manuscript type: Author's version (Accepted manuscript)

MDR DOI: https://doi.org/10.48505/nims.4527

First published URL: https://doi.org/10.1021/acsabm.0c00719

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Updated at: 2024-06-03 16:30:11 +0900

Published on MDR: 2024-06-03 16:30:11 +0900