# Single DNA hairpin nanowire based on self-hybridization chain reaction for sensitive ATP detection

https://mdr.nims.go.jp/datasets/a62d9821-98df-46b8-93df-1e3b36289d76

## Files

- [Single DNA hairpin nanowire based on self-hybridization chain reaction for sensitive ATP detection.pdf](https://mdr.nims.go.jp/filesets/f62455dc-3d1a-43ca-b796-8530f5dd3f68/download) ([Detail](https://mdr.nims.go.jp/filesets/f62455dc-3d1a-43ca-b796-8530f5dd3f68.md))
- [Supplementary Information.pdf](https://mdr.nims.go.jp/filesets/d33ac7da-5465-45f9-93fa-282060eef08d/download) ([Detail](https://mdr.nims.go.jp/filesets/d33ac7da-5465-45f9-93fa-282060eef08d.md))

## Id

a62d9821-98df-46b8-93df-1e3b36289d76

## Local identifier



## Visibility

open_to_public

## State

published

## Created at

2026-03-23T08:02:50.694863Z

## Updated at

2026-03-24T04:02:57.293620Z

## Published at

2026-03-24T07:24:14.934553Z

## Doi

https://doi.org/10.48505/nims.6232

## First published url

https://doi.org/10.1080/14686996.2026.2619337

## Date published

2026-12-31

## Recorded date published

2026-12-31

## Resource type

journal_article

## Manuscript type

accepted_manuscript

## Collection



## Title

- title: Single DNA hairpin nanowire based on self-hybridization chain reaction for
    sensitive ATP detection
  title_type: original
  lang: en

## Description

- description: Hybridization chain reaction (HCR), which typically consists of two
    hairpins for signal amplification, has emerged as a versatile tool in bioanalytical
    applications. Here, a novel HCR nanowire based on a single DNA hairpin structure
    is reported. The hairpin stem is rationally engineered with a palindromic sequence,
    which enables a self-hybridization chain reaction (SHCR) upon the introduction
    of the initiator DNA strand. Compared to the conventional two hairpin-based HCR
    nanowire, the single DNA hairpin-based SHCR nanowire achieves nearly a two-fold
    improvement in the signal-to-noise ratio and exhibits better selectivity for single-base
    mismatch. By integrating the initiator DNA strand with adenosine triphosphate
    (ATP) aptamer, the single DNA hairpin-based nanowire has been applied for sensitive
    ATP detection, capable of monitoring ATP both in living cells and that released
    from dead cancer cells post-radiotherapy. The SHCR nanowire we proposed here has
    significantly simplified the sequence design of HCR and holds promise as a potential
    alternative to the conventional HCR nanowire.
  description_type: abstract
  lang: en

## Creator

- name: Fengyi Lin
  role: author
  organization: Sichuan University
  department: a College of Chemistry
- name: Jing Liu
  role: author
- name: Yuxin Cheng
  role: author
- name: Min Li
  role: author
- name: Hong Zhang
  role: author
- name: Cuisong Zhou
  role: author
- name: Yong Guo
  role: author
- name: Dan Xiao
  role: author
- name: Peng Mi
  role: author
- name: Jianyuan Dai
  role: author

## Contact agent



## Publisher

organization: Taylor & Francis

## Managing organization



## Keyword

- subject: DNA nanowire
  schema: not_defined
- subject: self-hybridization chain reaction
  schema: not_defined
- subject: biosensor
  schema: not_defined
- subject: ATP detection
  schema: not_defined
- subject: cell death detection
  schema: not_defined

## Rights

- identifier: https://creativecommons.org/licenses/by/4.0/

## Other identifier(s)



## Data origin

- data_origin_type: other

## Embargo



## Journal

- title: Science and Technology of Advanced Materials
  issn: '14686996'
  volume: '27'
  issue: '1'
  article_number: '2619337'

## Conference



## Related item



## Funding



## Instrument



## Instrument operator



## Instrument managing organization



## Measurement method



## Specimen



## Chemical composition



## Structure for specimen



## Structural feature for specimen



## Specific property for specimen



## Process for specimen treatment



## Computational method



## Energy level/transition state



## Software



## Custom property



## Fileset

- id: f62455dc-3d1a-43ca-b796-8530f5dd3f68
  filename: Single DNA hairpin nanowire based on self-hybridization chain reaction
    for sensitive ATP detection.pdf
  content_type: application/pdf
  size: 4619132
  md5: 37a37553e1bec7b352e6e40175135874
- id: d33ac7da-5465-45f9-93fa-282060eef08d
  filename: Supplementary Information.pdf
  content_type: application/pdf
  size: 4832684
  md5: f93e3d41f68655defed14997a68fa7f7

## Thumbnail

fileset_id: f62455dc-3d1a-43ca-b796-8530f5dd3f68
filename: Single DNA hairpin nanowire based on self-hybridization chain reaction for
  sensitive ATP detection.pdf