# Smart Nanofiber Mesh with Locally Sustained Drug Release Enabled Synergistic Combination Therapy for Glioblastoma

https://mdr.nims.go.jp/datasets/a2e0fb18-037c-45bf-a122-dff44f138d35

## File

- [23_Nanomaterials.pdf](https://mdr.nims.go.jp/filesets/9975597b-1339-4e66-a371-92273dbef5ef/download) ([Detail](https://mdr.nims.go.jp/filesets/9975597b-1339-4e66-a371-92273dbef5ef.md))

## Id

a2e0fb18-037c-45bf-a122-dff44f138d35

## Local identifier



## Visibility

open_to_public

## State

published

## Created at

2024-08-19T10:57:14.114281Z

## Updated at

2024-08-28T03:30:28.798526Z

## Published at

2024-08-28T03:30:28.874790Z

## Doi



## First published url

https://doi.org/10.3390/nano13030414

## Date published

2023-01-19

## Recorded date published



## Resource type

journal_article

## Manuscript type

vor

## Collection



## Title

- title: Smart Nanofiber Mesh with Locally Sustained Drug Release Enabled Synergistic
    Combination Therapy for Glioblastoma
  title_type: original
  lang: en

## Description

- description: This study aims to propose a new treatment model for glioblastoma (GBM).
    The combination of chemotherapy, molecular targeted therapy and radiotherapy has
    been achieved in a highly simultaneous manner through the application of a safe,
    non-toxic, locally sustained drug-releasing composite Nanofiber mesh (NFM). The
    NFM consisted of biodegradable poly(ε-caprolactone) with temozolomide (TMZ) and
    17-allylamino-17-demethoxygeldanamycin (17AAG), which was used in radiation treatment.
    TMZ and 17AAG combination showed a synergistic cytotoxicity effect in the T98G
    cell model. TMZ and 17AAG induced a radiation-sensitization effect, respectively.
    The NFM containing 17AAG or TMZ, known as 17AAG-NFM and TMZ-NFM, enabled cumulative
    drug release of 34.1% and 39.7% within 35 days. Moreover, 17AAG+TMZ-NFM containing
    both drugs revealed a synergistic effect in relation to the NFM of a single agent.
    When combined with radiation, 17AAG+TMZ-NFM induced in an extremely powerful cytotoxic
    effect. These results confirmed the application of NFM can simultaneously allow
    multiple treatments to T98G cells. Each modality achieved a significant synergistic
    effect with the other, leading to a cascading amplification of the therapeutic
    effect. Due to the superior advantage of sustained drug release over a long period
    of time, NFM has the promise of clinically addressing the challenge of high recurrence
    of GBM post-operatively.
  description_type: abstract
  lang: und

## Creator

- name: Yinuo Li
  role: author
- name: Yoshitaka Matsumoto
  role: author
- name: Lili Chen
  role: author
  orcid: https://orcid.org/0000-0001-8290-5230
  organization: National Institute for Materials Science
- name: Yu Sugawara
  role: author
- name: Emiho Oe
  role: author
  orcid: https://orcid.org/0000-0001-7326-7740
  organization: National Institute for Materials Science
- name: Nanami Fujisawa
  role: author
  orcid: https://orcid.org/0000-0002-8894-1790
  organization: National Institute for Materials Science
- name: Mitsuhiro Ebara
  role: author
  orcid: https://orcid.org/0000-0002-7906-0350
  organization: National Institute for Materials Science
- name: Hideyuki Sakurai
  role: author

## Contact agent



## Publisher

organization: MDPI AG

## Managing organization



## Keyword

- subject: nanofibers glioblastoma cancer radiotherapy
  schema: not_defined

## Rights

- identifier: https://creativecommons.org/licenses/by/4.0/

## Other identifier(s)



## Data origin

- data_origin_type: other

## Embargo



## Journal

- title: Nanomaterials
  issn: '20794991'
  volume: '13'
  issue: '3'
  article_number: '414'

## Conference



## Related item



## Funding

- identifier: TK22-026
  funder_name: TIA Collaboration Program Exploration and Promotion Project “KAKEHASI”
- identifier: JP19H04476
  funder_name: JSPS KAKENHI Grant-in-Aid for Scientific Research
- identifier: JP20H05877
  funder_name: Grant-in-Aid for Transformative Research Areas

## Instrument



## Instrument operator



## Instrument managing organization



## Measurement method



## Specimen



## Chemical composition



## Structure for specimen



## Structural feature for specimen



## Specific property for specimen



## Process for specimen treatment



## Computational method



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## Fileset

- id: 9975597b-1339-4e66-a371-92273dbef5ef
  filename: 23_Nanomaterials.pdf
  content_type: application/pdf
  size: 976912
  md5: b4c2e36e3c5f673319a28fda3fcdc17c

## Thumbnail

fileset_id: 9975597b-1339-4e66-a371-92273dbef5ef
filename: 23_Nanomaterials.pdf