# Data-driven optimization of the in silico design of ionic liquids as interfacial cell culture fluids

https://mdr.nims.go.jp/datasets/9ba263f3-bb99-4436-85d2-487f1725db15

## File

- [Data-driven optimization of the in silico desi.pdf](https://mdr.nims.go.jp/filesets/2a00735e-44e0-49f6-a89c-fbd4f8651d57/download) ([Detail](https://mdr.nims.go.jp/filesets/2a00735e-44e0-49f6-a89c-fbd4f8651d57.md))

## Id

9ba263f3-bb99-4436-85d2-487f1725db15

## Local identifier



## Visibility

open_to_public

## State

published

## Created at

2024-11-28T05:07:02.389875Z

## Updated at

2024-12-05T03:47:22.233682Z

## Published at

2024-12-05T03:47:22.328823Z

## Doi



## First published url

https://doi.org/10.1080/14686996.2024.2418287

## Date published

2024-12-31

## Recorded date published

2024-12-31

## Resource type

journal_article

## Manuscript type

vor

## Collection



## Title

- title: Data-driven optimization of the in silico design of ionic liquids as interfacial
    cell culture fluids
  title_type: original
  lang: en

## Description

- description: As an alternative to conventional plastic dishes, the interface between
    water-immiscible hydrophobic fluids, such as perfluorocarbons and silicones, permits
    cell adhesion and growth. Thus, it is expected to replace the petroleum-derived
    products in a sustainable society. However, most hydrophobic fluids are cytotoxic,
    which limits the range of mechanical and chemical cues exposed to the cells. Using
    a data-driven approach, this study aimed to identify non-cytotoxic ionic liquids
    (ILs) as fluid culture platforms to take advantage of their ‘designer’ nature
    for broadening the possible physicochemical ranges exposed to cells and their
    repeated use owing to their high heat stability before their biological applications.
    The new candidates within the readily synthesized ammonium-type ILs were identified
    through the active cycle of regression and a limited number of cytotoxicity tests.
    Structure – cytotoxicity analysis indicated that the presence of multiple long
    alkyl branches was critical for low cytotoxicity. Particularly, we successfully
    cultured human mesenchymal stem cells (hMSCs) at the trihexylethylammonium trifluoromethylsulfonylimide
    interface and repeated their use after solvent extraction and heat sterilization.
    This study identified non-cytotoxic ILs that fulfill plastics’ 3 R (Reduce, Recycle,
    and Replace) requirements and opens new avenues for hMSC fate manipulation through
    mechanotransduction.
  description_type: abstract
  lang: eng

## Creator

- name: Jun Nakanishi
  role: author
  orcid: https://orcid.org/0000-0003-4457-6581
  organization: National Institute for Materials Science
  department: Research Center for Macromolecules and Biomaterials/Biomaterials Field/Mechanobiology
    Group
- name: Takeshi Ueki
  role: author
  orcid: https://orcid.org/0000-0001-9317-6280
  organization: National Institute for Materials Science
  department: Research Center for Macromolecules and Biomaterials/Biomaterials Field/Mechanobiology
    Group
- name: Sae Dieb
  role: author
  orcid: https://orcid.org/0000-0002-8111-2009
  organization: National Institute for Materials Science
  department: Center for Basic Research on Materials/Data-driven Materials Research
    Field/Data-driven Materials Design Group
- name: Hidenori Noguchi
  role: author
  orcid: https://orcid.org/0000-0001-9643-1689
  organization: National Institute for Materials Science
  department: Research Center for Energy and Environmental Materials (GREEN)/Battery
    and Cell Materials Field/Interface Electrochemistry Group
- name: Shota Yamamoto
  role: author
  orcid: https://orcid.org/0000-0002-7422-0968
  organization: National Institute for Materials Science
  department: Research Center for Macromolecules and Biomaterials/Biomaterials Field/Mechanobiology
    Group
- name: Keitaro Sodeyama
  role: author
  orcid: https://orcid.org/0000-0002-9228-0729
  organization: National Institute for Materials Science
  department: Center for Basic Research on Materials

## Contact agent



## Publisher

organization: Taylor & Francis

## Managing organization



## Keyword

- subject: cell scaffold
  schema: not_defined
- subject: ionic liquid
  schema: not_defined
- subject: data-driven science
  schema: not_defined
- subject: sustainability
  schema: not_defined
- subject: mechanotransduction
  schema: not_defined

## Rights

- identifier: https://creativecommons.org/licenses/by/4.0/

## Other identifier(s)



## Data origin

- data_origin_type: other

## Embargo



## Journal

- title: SCIENCE AND TECHNOLOGY OF ADVANCED MATERIALS
  issn: '14686996'
  volume: '25'
  issue: '1'
  article_number: '2418287'

## Conference



## Related item



## Funding

- identifier: 23K17481
  funder_name: JSPS
- identifier: 22H00596
  funder_name: JSPS

## Instrument



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## Fileset

- id: 2a00735e-44e0-49f6-a89c-fbd4f8651d57
  filename: Data-driven optimization of the in silico desi.pdf
  content_type: application/pdf
  size: 8813810
  md5: 960878770daa254f2a64672c91858a2b

## Thumbnail

fileset_id: 2a00735e-44e0-49f6-a89c-fbd4f8651d57
filename: Data-driven optimization of the in silico desi.pdf