# Sprayable Tissue Adhesive Microparticle–Magnetic Nanoparticle Composites for Local Cancer Hyperthermia https://mdr.nims.go.jp/datasets/9aaf32ca-866e-409a-9294-bebc5d875bd9 ## File - [Revised manuscript after approval_Biomater. Adv..docx](https://mdr.nims.go.jp/filesets/6d3eae20-77c1-417b-bbf2-a46924445114/download) ([Detail](https://mdr.nims.go.jp/filesets/6d3eae20-77c1-417b-bbf2-a46924445114.md)) ## Id 9aaf32ca-866e-409a-9294-bebc5d875bd9 ## Local identifier ## Visibility open_to_public ## State published ## Created at 2023-12-04T00:16:03.040843Z ## Updated at 2025-11-27T23:30:21.981335Z ## Published at 2025-11-27T23:22:45.525822Z ## Doi https://doi.org/10.48505/nims.4285 ## First published url https://doi.org/10.1016/j.bioadv.2023.213707 ## Date published 2023-11-27 ## Recorded date published 2024-1 ## Resource type journal_article ## Manuscript type accepted_manuscript ## Collection ## Title - title: 'Sprayable Tissue Adhesive Microparticle–Magnetic Nanoparticle Composites for Local Cancer Hyperthermia ' title_type: original lang: en ## Description - description: Incomplete removal of early-stage gastrointestinal cancers by endoscopic treatments often leads to recurrence induced by residual cancer cells. To completely remove or kill cancer tissues and cells and prevent recurrence, chemotherapy, radiotherapy, and hyperthermia using biomaterials with drugs or nanomaterials are usually administered following endoscopic treatments. However, there are no biomaterials that can be applied using endoscopic devices to locally kill cancer tissues and cells. We previously reported that decyl group-modified Alaska pollock gelatin-based microparticles (denoted C10MPs) can adhere to gastrointestinal tissues under wet conditions through the formation of a colloidal gel driven by hydrophobic interactions. In this study, we combined C10MPs with superparamagnetic iron oxide nanoparticles (SPIONs) to develop a sprayable heat-generating nanomaterial (denoted SP/C10MP) for local hyperthermia of gastrointestinal cancers. The rheological property, tissue adhesion strength, burst strength, and underwater stability of SP/C10MP were improved through decyl group modification and SPION addition. Moreover, SP/C10MP that adhered to gastrointestinal tissues formed a colloidal gel, which locally generated heat in response to an alternating magnetic field. SP/C10MP successfully killed cancer tissues and cells in colon cancer-bearing mouse models in vitro and in vivo. Therefore, SP/C10MP has the potential to locally kill residual cancer tissues and cells after endoscopic treatments. description_type: abstract lang: eng ## Creator - name: 伊藤 椎真 role: author organization: National Institute for Materials Science department: Research Center for Macromolecules and Biomaterials/Biomaterials Field/Polymeric Biomaterials Group ror: https://ror.org/026v1ze26 - name: 長坂 和寛 role: author organization: National Institute for Materials Science department: Research Center for Macromolecules and Biomaterials/Biomaterials Field/Polymeric Biomaterials Group ror: https://ror.org/026v1ze26 - name: 小松 ひより role: author orcid: https://orcid.org/0000-0002-2525-1362 organization: National Institute for Materials Science department: Research Center for Macromolecules and Biomaterials/Biomaterials Field/Polymeric Biomaterials Group ror: https://ror.org/026v1ze26 - name: 間宮 広明 role: author orcid: https://orcid.org/0000-0002-7840-3008 organization: National Institute for Materials Science department: Research Center for Magnetic and Spintronic Materials/Green Magnetic Materials Group ror: https://ror.org/026v1ze26 - name: 竹口 雅樹 role: author orcid: https://orcid.org/0000-0002-0282-6020 organization: National Institute for Materials Science department: Center for Basic Research on Materials/Advanced Materials Characterization Field/In-situ Electron Microscopy Technique Group ror: https://ror.org/026v1ze26 - name: 西口 昭広 role: author orcid: https://orcid.org/0000-0002-3160-6385 organization: National Institute for Materials Science department: Research Center for Macromolecules and Biomaterials/Biomaterials Field/Polymeric Biomaterials Group ror: https://ror.org/026v1ze26 - name: 田口 哲志 role: author orcid: https://orcid.org/0000-0003-2541-2530 organization: National Institute for Materials Science department: Research Center for Macromolecules and Biomaterials/Biomaterials Field/Polymeric Biomaterials Group ror: https://ror.org/026v1ze26 ## Contact agent ## Publisher organization: Elsevier B.V. ## Managing organization ## Keyword - subject: Endoscope surgery schema: not_defined - subject: local hyperthermia schema: not_defined - subject: tissue adhesion schema: not_defined - subject: underwater stability schema: not_defined - subject: hydrophobic interaction schema: not_defined ## Rights - identifier: https://creativecommons.org/licenses/by-nc-nd/4.0/ ## Other identifier(s) ## Data origin - data_origin_type: other ## Embargo start_date: 2023-11-28 end_date: 2025-11-28 ## Journal - title: Biomaterials Advances issn: '27729508' volume: '156' article_number: '213707' ## Conference ## Related item ## Funding - identifier: 22J20039 funder_name: JSPS科研費 - identifier: 23H01718 funder_name: JSPS科研費 - identifier: 22H03962 funder_name: JSPS科研費 - identifier: 22K19947 funder_name: JSPS科研費 ## Instrument ## Instrument operator ## Instrument managing organization ## Measurement method ## Specimen ## Chemical composition ## Structure for specimen ## Structural feature for specimen ## Specific property for specimen ## Process for specimen treatment ## Computational method ## Energy level/transition state ## Software ## Custom property ## Fileset - id: 6d3eae20-77c1-417b-bbf2-a46924445114 filename: Revised manuscript after approval_Biomater. Adv..docx content_type: application/vnd.openxmlformats-officedocument.wordprocessingml.document size: 4306110 md5: 56c585bdead76120530f7bcc20cc101a ## Thumbnail fileset_id: 6d3eae20-77c1-417b-bbf2-a46924445114 filename: Revised manuscript after approval_Biomater. Adv..docx