# Impact of hydrophobic modification on biocompatibility of Alaska pollock gelatin microparticles

https://mdr.nims.go.jp/datasets/9a272db2-ca6f-4211-a25e-a229b7b989af

## File

- [ANSC-D-24-00312_R2 accepted manuscript.pdf](https://mdr.nims.go.jp/filesets/0c74f7f6-dd31-42dd-835d-4b78efc40d78/download) ([Detail](https://mdr.nims.go.jp/filesets/0c74f7f6-dd31-42dd-835d-4b78efc40d78.md))

## Id

9a272db2-ca6f-4211-a25e-a229b7b989af

## Local identifier



## Visibility

open_to_public

## State

published

## Created at

2024-09-09T09:15:33.100160Z

## Updated at

2025-10-21T07:16:33.536386Z

## Published at

2025-10-21T07:14:42.440689Z

## Doi

https://doi.org/10.48505/nims.5081

## First published url

https://doi.org/10.1007/s44211-024-00643-2

## Date published

2024-08-09

## Recorded date published

2024-11

## Resource type

journal_article

## Manuscript type

accepted_manuscript

## Collection



## Title

- title: Impact of hydrophobic modification on biocompatibility of Alaska pollock
    gelatin microparticles
  title_type: original
  lang: en

## Description

- description: This study investigates the impact of hydrophobic modification on the
    immunogenicity, cytotoxicity, and inflammatory response of Alaska pollock gelatin
    (ApGltn) microparticles (MPs). Gelatin, known for its inherent biocompatibility,
    was modified with decyl group (C10) to explore potential alterations in its interaction
    with the immune system.  Immunogenicity was evaluated through the measurement
    of material-specific IgM and IgG responses, indicating no significant increase
    post-modification. Cytotoxicity against Caco-2 cell lines and NF-kB-mediated LPS-induced
    inflammation were also assessed, revealing no exacerbation by the modified MPs.
    Furthermore, C10-modification with different types of linkage such as secondary
    amine and amide structure did not influence immune reactivity. These findings
    suggest that C10-modification maintains the non-immunogenicity and biocompatibility
    of gelatin MPs, supporting their potential use in biomedical applications.
  description_type: abstract
  lang: und

## Creator

- name: Ying Chuin Yee
  role: author
- name: Takeshi Mori
  role: author
  orcid: https://orcid.org/0000-0002-1821-5427
- name: Shima Ito
  role: author
  orcid: https://orcid.org/0000-0002-3233-617X
  organization: National Institute for Materials Science
  ror: https://ror.org/026v1ze26
- name: Tetsushi Taguchi
  role: author
  orcid: https://orcid.org/0000-0003-2541-2530
  organization: National Institute for Materials Science
  ror: https://ror.org/026v1ze26
- name: Yoshiki Katayama
  role: author

## Contact agent



## Publisher

organization: Springer Science and Business Media LLC

## Managing organization



## Keyword

- subject: Alaska pollock gelatin
  schema: not_defined
- subject: Microparticles
  schema: not_defined
- subject: Hydrophobic modification
  schema: not_defined

## Rights

- description: 'This version of the article has been accepted for publication, after
    peer review (when applicable) and is subject to Springer Nature’s AM terms of
    use, but is not the Version of Record and does not reflect post-acceptance improvements,
    or any corrections. The Version of Record is available online at: http://dx.doi.org/10.1007/s44211-024-00643-2'
  identifier: http://rightsstatements.org/vocab/InC/1.0/

## Other identifier(s)



## Data origin

- data_origin_type: other

## Embargo

start_date: 2024-08-09
end_date: 2025-08-09

## Journal

- title: Analytical Sciences
  issn: '09106340'
  volume: '40'
  start_page: 2053
  end_page: 2061

## Conference



## Related item



## Funding

- identifier: 20H05876
  funder_name: Grant-in-Aid for Transformative Research Areas
- identifier: 20H05872
  funder_name: Grant-in-Aid for Transformative Research Areas

## Instrument



## Instrument operator



## Instrument managing organization



## Measurement method



## Specimen



## Chemical composition



## Structure for specimen



## Structural feature for specimen



## Specific property for specimen



## Process for specimen treatment



## Computational method



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## Custom property



## Fileset

- id: 0c74f7f6-dd31-42dd-835d-4b78efc40d78
  filename: ANSC-D-24-00312_R2 accepted manuscript.pdf
  content_type: application/pdf
  size: 1339647
  md5: 636de841bddd89ec5cd0eb84ca2e13d2

## Thumbnail

fileset_id: 0c74f7f6-dd31-42dd-835d-4b78efc40d78
filename: ANSC-D-24-00312_R2 accepted manuscript.pdf