# Crystal Nucleation in Ibuprofen Glass: Possible Relevance between the Characteristic Length of the Cooperatively Rearranging Region and the Size of Crystal Nuclei

https://mdr.nims.go.jp/datasets/9718c37b-4344-45b6-bd51-9775c611c3cf

## File

- [2025JPCB_IBP.pdf](https://mdr.nims.go.jp/filesets/f5788ccc-0353-4bc4-9f44-98a3065307b5/download) ([Detail](https://mdr.nims.go.jp/filesets/f5788ccc-0353-4bc4-9f44-98a3065307b5.md))

## Id

9718c37b-4344-45b6-bd51-9775c611c3cf

## Local identifier



## Visibility

open_to_public

## State

published

## Created at

2025-04-30T01:25:59.394318Z

## Updated at

2025-11-25T03:30:10.150686Z

## Published at

2025-11-25T03:23:33.522793Z

## Doi



## First published url

https://doi.org/10.1021/acs.jpcb.4c07005

## Date published

2025-02-20

## Recorded date published

2025-2-20

## Resource type

journal_article

## Manuscript type

vor

## Collection



## Title

- title: 'Crystal Nucleation in Ibuprofen Glass: Possible Relevance between the Characteristic
    Length of the Cooperatively Rearranging Region and the Size of Crystal Nuclei'
  title_type: original
  lang: en

## Description

- description: Crystallization behavior of ibuprofen glass was investigated with focus
    on the nucleation process and its possible relevance to the cooperatively rearranging
    region (CRR). The nucleation temperature range of ibuprofen glass was determined
    by annealing it at various temperatures, followed by observation of the probability
    of cold crystallization. The temperature to provide the highest probability of
    nucleation was −15 °C. The effect of the addition of a polymer was also investigated
    to find that it enhanced and suppressed the crystallization depending on the polymer
    species and its amount added. The added polymer seemed to influence both nucleation
    and crystal growth processes by decreasing the glass/nuclei interfacial tension
    and increasing viscosity, respectively. In addition, the coincidence of the size
    of CRR in the presence of the polymer with the critical size of nuclei was assumed
    to enhance nucleation. This finding provides a novel viewpoint for clarifying
    the nucleation mechanism from supercooled liquids and glasses.
  description_type: abstract
  lang: und

## Creator

- name: Kohsaku Kawakami
  role: author
  orcid: https://orcid.org/0000-0002-3466-9365
- name: Kaoru Ohyama
  role: author

## Contact agent



## Publisher

organization: American Chemical Society (ACS)

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## Keyword

- subject: Pharmaceutical glass
  schema: not_defined
- subject: Nucleation
  schema: not_defined
- subject: Crystallization
  schema: not_defined
- subject: Cooperatively rearranging region
  schema: not_defined

## Rights

- identifier: https://creativecommons.org/licenses/by/4.0/

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## Embargo



## Journal

- title: The Journal of Physical Chemistry B
  issn: '15206106'
  volume: '129'
  issue: '7'
  start_page: 2096
  end_page: 2104

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## Fileset

- id: f5788ccc-0353-4bc4-9f44-98a3065307b5
  filename: 2025JPCB_IBP.pdf
  content_type: application/pdf
  size: 5468728
  md5: a6f3279ba6133b91b18e455b923479a7

## Thumbnail

fileset_id: f5788ccc-0353-4bc4-9f44-98a3065307b5
filename: 2025JPCB_IBP.pdf