# Cancer Microenvironment‐Stimulated Mesenchymal Stem Cells in an Indirect Co‐Culture System Influence Cancer Cell Growth and Apoptosis

https://mdr.nims.go.jp/datasets/94b5e029-3a11-4ce6-8d61-8f3e706324dc

## File

- [Pragati_Advanced biology_FinalFile.pdf](https://mdr.nims.go.jp/filesets/dbea300e-3960-4c4a-9a95-ec65e85b5a3b/download) ([Detail](https://mdr.nims.go.jp/filesets/dbea300e-3960-4c4a-9a95-ec65e85b5a3b.md))

## Id

94b5e029-3a11-4ce6-8d61-8f3e706324dc

## Local identifier



## Visibility

open_to_public

## State

published

## Created at

2025-12-22T01:46:22.170569Z

## Updated at

2026-04-30T03:01:11.491392Z

## Published at

2026-08-22T23:26:29.282145Z

## Doi

https://doi.org/10.48505/nims.6045

## First published url

https://doi.org/10.1002/adbi.202500291

## Date published

2025-08-23

## Recorded date published

2025-12

## Resource type

journal_article

## Manuscript type

accepted_manuscript

## Collection



## Title

- title: Cancer Microenvironment‐Stimulated Mesenchymal Stem Cells in an Indirect
    Co‐Culture System Influence Cancer Cell Growth and Apoptosis
  title_type: original
  lang: en

## Description

- description: 'This study assesses whether human mesenchymal stem cells (hMSCs) of
    shared ancestry exhibit similar tumorigenic properties. Bone marrow-derived (hBM-MSCs)
    and umbilical cord-derived (hUC-MSCs) MSCs embedded in collagen are cultured in
    conditioned media from lung adenocarcinoma (A549) cells to mimic the extracellular
    matrix and soluble cues of the cancer microenvironment. '
  description_type: abstract
  lang: und

## Creator

- name: Pragati Sharma
  role: author
  orcid: https://orcid.org/0009-0000-3028-0670
- name: Jun Nakanishi
  role: author
  orcid: https://orcid.org/0000-0003-4457-6581
- name: Subha Narayan Rath
  role: author
  orcid: https://orcid.org/0000-0002-3414-2328

## Contact agent



## Publisher

organization: Wiley

## Managing organization



## Keyword

- subject: Tumor Microenvironments
  schema: not_defined
- subject: Lung cancer
  schema: not_defined
- subject: Mesenchymal Stem Cells
  schema: not_defined
- subject: Extracellular Matrix
  schema: not_defined
- subject: Cancer-associated Fibroblasts
  schema: not_defined

## Rights

- description: 'This is the peer reviewed version of the following article: P. Sharma,
    J. Nakanishi, and S. N. Rath, “ Cancer Microenvironment-Stimulated Mesenchymal
    Stem Cells in an Indirect Co-Culture System Influence Cancer Cell Growth and Apoptosis.”
    Adv. Biology 9, no. 12 (2025): e00291, which has been published in final form
    at https://doi.org/10.1002/adbi.202500291. This article may be used for non-commercial
    purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived
    Versions. This article may not be enhanced, enriched or otherwise transformed
    into a derivative work, without express permission from Wiley or by statutory
    rights under applicable legislation. Copyright notices must not be removed, obscured
    or modified. The article must be linked to Wiley’s version of record on Wiley
    Online Library and any embedding, framing or otherwise making available the article
    or pages thereof by third parties from platforms, services and websites other
    than Wiley Online Library must be prohibited.'
  identifier: http://rightsstatements.org/vocab/InC/1.0/

## Other identifier(s)



## Data origin

- data_origin_type: other

## Embargo

start_date: 2025-08-23
end_date: 2026-08-23

## Journal

- title: Advanced Biology
  issn: '27010198'
  volume: '9'
  issue: '12'
  article_number: e00291

## Conference



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## Funding

- funder_name: National Institute for Materials Science
- identifier: 23K17481
  funder_name: Japan Society for the Promotion of Science

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## Fileset

- id: dbea300e-3960-4c4a-9a95-ec65e85b5a3b
  filename: Pragati_Advanced biology_FinalFile.pdf
  content_type: application/pdf
  size: 1193973
  md5: d12a5860f9baf04fc233a8a10b7af9c5

## Thumbnail

fileset_id: dbea300e-3960-4c4a-9a95-ec65e85b5a3b
filename: Pragati_Advanced biology_FinalFile.pdf