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This study assesses whether human mesenchymal stem cells (hMSCs) of shared ancestry exhibit similar tumorigenic properties. Bone marrow-derived (hBM-MSCs) and umbilical cord-derived (hUC-MSCs) MSCs embedded in collagen are cultured in conditioned media from lung adenocarcinoma (A549) cells to mimic the extracellular matrix and soluble cues of the cancer microenvironment.

権利情報:

• In Copyright
  

  This is the peer reviewed version of the following article: P. Sharma, J. Nakanishi, and S. N. Rath, “ Cancer Microenvironment-Stimulated Mesenchymal Stem Cells in an Indirect Co-Culture System Influence Cancer Cell Growth and Apoptosis.” Adv. Biology 9, no. 12 (2025): e00291, which has been published in final form at https://doi.org/10.1002/adbi.202500291. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages thereof by third parties from platforms, services and websites other than Wiley Online Library must be prohibited.

キーワード: Tumor Microenvironments, Lung cancer, Mesenchymal Stem Cells, Extracellular Matrix, Cancer-associated Fibroblasts

刊行年月日: 2025-08-23

出版者: Wiley

掲載誌:

• Advanced Biology (ISSN: 27010198) vol. 9 issue. 12 e00291

研究助成金:

• National Institute for Materials Science
• Japan Society for the Promotion of Science 23K17481

原稿種別: 著者最終稿 (Accepted manuscript)

MDR DOI: https://doi.org/10.48505/nims.6045

公開URL: https://doi.org/10.1002/adbi.202500291

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更新時刻: 2026-04-30 12:01:11 +0900

MDRでの公開時刻: 2026-08-23 08:26:29 +0900