# Biological characterization of breast cancer spheroid formed by fast fabrication method

https://mdr.nims.go.jp/datasets/93c23e2f-bbf2-4348-9b56-61e9ac78ad40

## File

- [IVM2024_preprint.pdf](https://mdr.nims.go.jp/filesets/4bbd5729-9e02-4997-9666-5ac67a952e2e/download) ([Detail](https://mdr.nims.go.jp/filesets/4bbd5729-9e02-4997-9666-5ac67a952e2e.md))

## Id

93c23e2f-bbf2-4348-9b56-61e9ac78ad40

## Local identifier



## Visibility

open_to_public

## State

published

## Created at

2024-08-09T07:23:38.591467Z

## Updated at

2024-08-29T07:30:30.580369Z

## Published at

2024-08-29T07:30:30.687703Z

## Doi

https://doi.org/10.48505/nims.4701

## First published url

https://doi.org/10.1007/s44164-024-00066-3

## Date published

2024-02-13

## Recorded date published



## Resource type

journal_article

## Manuscript type

authors_original

## Collection



## Title

- title: Biological characterization of breast cancer spheroid formed by fast fabrication
    method
  title_type: original
  lang: en

## Description

- description: Using superhydrophobic microwells fabricated by cutting macroporous
    monoliths, we developed a fabrication method that allows anyone to fabricate and
    mature cancer spheroids. The biological behavior of the fabricated breast cancer
    spheroids was evaluated under normoxic and hypoxic conditions. The spheroids obtained
    by this method were highly reproducible and functioned as 3D tumor tissues even
    after a short culture period. The method has a wide range of potential applications
    in cancer research, such as elucidating the mechanisms of tumor invasion and metastasis,
    and screening for anticancer drugs.
  description_type: abstract
  lang: en
- description: モノリス型多孔体の切削により作製された超撥水性マイクロウェルを用い、誰でもがんスフェロイドを作製・成熟させることができる作製法を開発した。また、作製した乳がんスフェロイドの生物学的挙動を、正常酸素条件下および低酸素条件下で評価した。本作製法で得られたスフェロイドは再現性が高く、短い培養期間でも3次元腫瘍組織として機能した。腫瘍の浸潤や転移のメカニズムの解明、抗がん剤のスクリーニングなど、がん研究において幅広い応用可能性がある。
  description_type: abstract
  lang: und

## Creator

- name: Yuta Iijima
  role: author
- name: Norino Uenaka
  role: author
- name: Mayu Morimoto
  role: author
- name: Daiki Sato
  role: author
- name: Satomi Hirose
  role: author
- name: Naoyoshi Sakitani
  role: author
- name: Masahiro Shinohara
  role: author
- name: Kenichi Funamoto
  role: author
- name: Gen Hayase
  role: author
  orcid: https://orcid.org/0000-0003-1970-6129
  organization: National Institute for Materials Science
  ror: https://ror.org/026v1ze26
- name: Daisuke Yoshino
  role: author

## Contact agent



## Publisher

organization: Springer Science and Business Media LLC

## Managing organization



## Keyword

- subject: cancer spheroid
  schema: not_defined
- subject: fast fabrication
  schema: not_defined
- subject: superhydrophobic substrate
  schema: not_defined
- subject: in vitro model
  schema: not_defined
- subject: hypoxia
  schema: not_defined

## Rights

- identifier: http://rightsstatements.org/vocab/InC/1.0/

## Other identifier(s)



## Data origin

- data_origin_type: other

## Embargo



## Journal

- title: In vitro models
  issn: '27313441'
  volume: '3'
  issue: '1'
  start_page: 19
  end_page: 32

## Conference



## Related item



## Funding

- funder_name: Nakatani Foundation for Advancement of Measuring Technologies in Biomedical
    Engineering
- identifier: 21K19893
  funder_name: Japan Society for the Promotion of Science

## Instrument



## Instrument operator



## Instrument managing organization



## Measurement method



## Specimen



## Chemical composition



## Structure for specimen



## Structural feature for specimen



## Specific property for specimen



## Process for specimen treatment



## Computational method



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## Fileset

- id: 4bbd5729-9e02-4997-9666-5ac67a952e2e
  filename: IVM2024_preprint.pdf
  content_type: application/pdf
  size: 4949976
  md5: 948b2591bbfdd3ada03e753ae2d3cc65

## Thumbnail

fileset_id: 4bbd5729-9e02-4997-9666-5ac67a952e2e
filename: IVM2024_preprint.pdf