# Polymeric soft materials with molecular recognition: From static binding to dynamic functions in gels, particles, and interfaces

https://mdr.nims.go.jp/datasets/91a5f992-8371-42e0-91d9-792caea762c9

## File

- [Polymeric soft materials with molecular recognition  from static binding to dynamic functions in gels  particles  and interfaces.pdf](https://mdr.nims.go.jp/filesets/496eae30-ba26-43ee-8dd7-1a0c59cb4468/download) ([Detail](https://mdr.nims.go.jp/filesets/496eae30-ba26-43ee-8dd7-1a0c59cb4468.md))

## Id

91a5f992-8371-42e0-91d9-792caea762c9

## Local identifier



## Visibility

open_to_public

## State

published

## Created at

2026-05-14T01:58:49.171712Z

## Updated at

2026-05-14T07:09:57.884581Z

## Published at

2026-05-14T09:28:11.739355Z

## Doi

https://doi.org/10.48505/nims.6295

## First published url

https://doi.org/10.1080/14686996.2026.2664156

## Date published

2026-12-31

## Recorded date published

2026-12-31

## Resource type

journal_article

## Manuscript type

accepted_manuscript

## Collection



## Title

- title: 'Polymeric soft materials with molecular recognition: From static binding
    to dynamic functions in gels, particles, and interfaces'
  title_type: original
  lang: en

## Description

- description: Molecular recognition governs important chemical events in biology
    from enzyme catalysis to immune defense and cellular signal transduction, where
    specificity is expressed not only as affinity but also as regulated, state-dependent
    function. Translating these principles into synthetic materials and systems has
    stimulated the development of polymeric soft materials in which binding events
    are coupled to macroscopic responses. This review focuses on polymeric soft materials
    such as hydrogels, particles, and interfaces that integrate recognition moieties,
    including noncovalent and host-guest interactions, biomolecular ligands, and molecularly
    imprinted cavities, and describes coupling mechanisms that convert binding into
    macroscopic structural change, transport regulation, and device-readable signals.
    In macroscopic stimuli-responsive hydrogels, molecular recognition can induce
    changes in effective crosslink density, hydration, and chain conformation, thereby
    enabling autonomous gating and representative concepts for glucose-responsive
    insulin delivery. Miniaturization to particles and micro/nanogels increases accessible
    surface area and shortens diffusion paths, which often accelerates response kinetics
    and enhances targeted therapeutics and controlled drug release. At polymer interfaces,
    especially membranes, thin films, and layers, molecular recognition must be designed
    together with transport pathways. Antifouling architectures, including zwitterionic
    polymers, are also important for maintaining selectivity in surface-sensitive
    measurements such as surface plasmon resonance (SPR). Across these platforms,
    practical performance is frequently governed not by binding affinity alone but
    by transport accessibility, layer thickness, and baseline stability against nonspecific
    adsorption and signal drift. Focusing on the relationships between structures
    and functions, this review summarizes current progress and outlines design strategies
    for smart polymer materials that translate molecular binding into functional outputs.
  description_type: abstract
  lang: en

## Creator

- name: Takashi Miyata
  role: author
  organization: Kansai University
  department: a Department of Chemistry and Materials Engineering

## Contact agent



## Publisher

organization: Taylor & Francis

## Managing organization



## Keyword

- subject: 'Hydrogels: particles: microgels'
  schema: not_defined
- subject: nanogels
  schema: not_defined
- subject: membranes
  schema: not_defined
- subject: layers
  schema: not_defined
- subject: molecular recognition
  schema: not_defined
- subject: molecular complex
  schema: not_defined
- subject: molecular imprinting
  schema: not_defined
- subject: stimuli-responsive polymer
  schema: not_defined

## Rights

- identifier: https://creativecommons.org/licenses/by/4.0/

## Other identifier(s)



## Data origin

- data_origin_type: other

## Embargo



## Journal

- title: Science and Technology of Advanced Materials
  issn: '14686996'
  volume: '27'
  issue: '1'
  article_number: '2664156'

## Conference



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## Instrument



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## Measurement method



## Specimen



## Chemical composition



## Structure for specimen



## Structural feature for specimen



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## Process for specimen treatment



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## Fileset

- id: 496eae30-ba26-43ee-8dd7-1a0c59cb4468
  filename: Polymeric soft materials with molecular recognition  from static binding
    to dynamic functions in gels  particles  and interfaces.pdf
  content_type: application/pdf
  size: 7807982
  md5: c0e62ed047d84cb6c8307430a44e6098

## Thumbnail

fileset_id: 496eae30-ba26-43ee-8dd7-1a0c59cb4468
filename: Polymeric soft materials with molecular recognition  from static binding
  to dynamic functions in gels  particles  and interfaces.pdf