# Poly(ARTEMA), a novel artesunate-based polymer induces ferroptosis in breast cancer cells

https://mdr.nims.go.jp/datasets/9058d120-4a20-49cf-bd07-a80bbaf59fa0

## File

- [25_STAM.pdf](https://mdr.nims.go.jp/filesets/826edc69-ac3c-4ae6-856b-5c09b4806b55/download) ([Detail](https://mdr.nims.go.jp/filesets/826edc69-ac3c-4ae6-856b-5c09b4806b55.md))

## Id

9058d120-4a20-49cf-bd07-a80bbaf59fa0

## Local identifier



## Visibility

open_to_public

## State

published

## Created at

2025-12-16T00:24:13.818944Z

## Updated at

2025-12-16T00:51:52.823066Z

## Published at

2025-12-19T05:11:47.309465Z

## Doi



## First published url

https://doi.org/10.1080/14686996.2025.2482514

## Date published

2025-12-31

## Recorded date published

2025-12-31

## Resource type

journal_article

## Manuscript type

vor

## Collection



## Title

- title: Poly(ARTEMA), a novel artesunate-based polymer induces ferroptosis in breast
    cancer cells
  title_type: original
  lang: en

## Description

- description: 'Ferroptosis, a form of non-apoptotic cell death, is emerging as a
    promising strategy for cancer therapy. Artesunate (ART), an extract obtained from
    the traditional Chinese medicine Qinghaosu, has been shown to exhibit anti-cancer
    activity by inducing ferroptosis in cancer cells. While previous research has
    focused on incorporating ART monomer into drug delivery systems for enhanced cancer
    targeting, this study presents 2-methacryloyloxyethyl ART polymer (poly(ARTEMA)),
    a novel polymer synthesized from ART for the first time. Our goal was evaluation
    of poly(ARTEMA) anticancer potential on breast cancer cells. First, we synthesized
    ARTEMA using esterification followed by its polymerization using the reversible
    addition-fragmentation chain transfer (RAFT) polymerization method. We evaluated
    its mechanism of action, focusing on two key pathways: temperature-triggered singlet
    oxygen generation and ferrous ions (Fe2+) release, both of which contribute to
    ferroptosis. Our results demonstrate that poly(ARTEMA) selectively generates singlet
    oxygen and Fe2+ due to the endoperoxide crosslinks, leading to cell death in breast
    cancer cells. We also investigated the anti-cancer potential of poly(ARTEMA) on
    breast cancer cells with and without a ferroptosis inhibitor. The IC50 values
    were 125 µM for the MCF-7 cancer cell line and 300 µM for the normal MCF-10 cell
    line, indicating enhanced toxicity toward cancer cell lines. These findings suggested
    that poly(ARTEMA) induces ferroptosis in cancer cells and may serve as a promising
    candidate for cancer therapy with minimal cytotoxicity. To the best of our knowledge,
    this report may be the first that successfully synthesized poly(ARTEMA) using
    ART, with its anticancer potential evaluation.'
  description_type: abstract
  lang: und

## Creator

- name: Natsumi Ito
  role: author
  organization: National Institute for Materials Science
- name: Ahmed Nabil
  role: author
- name: Koichiro Uto
  role: author
  orcid: https://orcid.org/0000-0001-7091-0585
  organization: National Institute for Materials Science
- name: Mitsuhiro Ebara
  role: author
  orcid: https://orcid.org/0000-0002-7906-0350
  organization: National Institute for Materials Science

## Contact agent



## Publisher

organization: Informa UK Limited

## Managing organization



## Keyword

- subject: artesunate
  schema: not_defined
- subject: ferroptosis
  schema: not_defined
- subject: cancer
  schema: not_defined

## Rights

- identifier: https://creativecommons.org/licenses/by-nc/4.0/
  date_licensed: 2025-04-15

## Other identifier(s)



## Data origin

- data_origin_type: other

## Embargo



## Journal

- title: Science and Technology of Advanced Materials
  issn: '14686996'
  volume: '26'
  issue: '1'
  article_number: '2482514'

## Conference



## Related item



## Funding

- funder_name: JSPS KAKENHI

## Instrument



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## Measurement method



## Specimen



## Chemical composition



## Structure for specimen



## Structural feature for specimen



## Specific property for specimen



## Process for specimen treatment



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## Fileset

- id: 826edc69-ac3c-4ae6-856b-5c09b4806b55
  filename: 25_STAM.pdf
  content_type: application/pdf
  size: 3436723
  md5: f4245b2c9b0e9946fb96489236cb84d6

## Thumbnail

fileset_id: 826edc69-ac3c-4ae6-856b-5c09b4806b55
filename: 25_STAM.pdf