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説明:

In this study, we developed a facile synthetic method for constructing a highly strained Tyr C6–to–Trp C5′ linkage. This approach enables the convergent installation of diverse biaryl units into peptide linkers via electrochemically assisted Ni-catalyzed cross-electrophile coupling, followed by regioselective Larock macrocyclization. Using this methodology, we accomplished the total synthesis of the ribosomally synthesized and post-translationally modified peptide (RiPP) micitide 982. Moreover, this synthetic strategy provides broad flexibility, allowing the incorporation of a wide variety of biaryl motifs.

権利情報:

• Creative Commons BY Attribution 4.0 International
  

キーワード: Biaryl Peptides, Electrochemistry, Noncanonical Cyclic Peptides, Ribosomal Peptide Natural Products, Total Synthesis

刊行年月日: 2025-11-10

出版者: Wiley

掲載誌:

• Angewandte Chemie International Edition (ISSN: 00448249) vol. 64 issue. 46 e202516053

研究助成金:

• City University of Hong Kong 7020157

原稿種別: 出版者版 (Version of record)

MDR DOI:

公開URL: https://doi.org/10.1002/anie.202516053

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更新時刻: 2026-09-04 09:38:35 +0900

MDRでの公開時刻: 2026-09-04 12:24:07 +0900