# An injectable hyperthermic nanofiber mesh with switchable drug release to stimulate chemotherapy potency

https://mdr.nims.go.jp/datasets/8b762a1d-33f5-48dd-9799-38df793b505e

## Files

- [22_BioengBiotech.pdf](https://mdr.nims.go.jp/filesets/98103a90-2121-4f3d-95d1-9de9e9c29261/download) ([Detail](https://mdr.nims.go.jp/filesets/98103a90-2121-4f3d-95d1-9de9e9c29261.md))

## Id

8b762a1d-33f5-48dd-9799-38df793b505e

## Local identifier



## Visibility

open_to_public

## State

published

## Created at

2024-08-19T10:55:29.538041Z

## Updated at

2024-08-28T03:30:25.571168Z

## Published at

2024-08-28T03:30:25.648346Z

## Doi



## First published url

https://doi.org/10.3389/fbioe.2022.1046147

## Date published

2022-11-03

## Recorded date published



## Resource type

journal_article

## Manuscript type

vor

## Collection



## Title

- title: An injectable hyperthermic nanofiber mesh with switchable drug release to
    stimulate chemotherapy potency
  title_type: original
  lang: en

## Description

- description: We developed a smart nanofiber mesh (SNM) with anticancer abilities,
    injectability, and fast recovery from irregular to non-compressible shapes. The
    mesh can be injected at the tumor site to modulate and control anticancer effects
    by loading the chemotherapeutic drug, paclitaxel (PTX), and magnetic nanoparticles
    (MNPs). The storage modulus of the mesh decreases when applied with a certain
    shear strain, and the mesh can pass through a 14-gauge needle. Moreover, the fibrous
    morphology is maintained even after injection. In heat-generation measurements,
    the mesh achieved an effective temperature of mild hyperthermia (41–43°C) within
    5 min of exposure to alternating magnetic field (AMF) irradiation. An electrospinning
    method was employed to fabricate the mesh using a copolymer of N-isopropyl acrylamide
    (NIPAAm) and N-hydroxyethyl acrylamide (HMAAm), whose phase transition temperature
    was adjusted to a mildly hyperthermic temperature range. Polyvinyl alcohol (PVA)
    was also incorporated to add a shear-thinning property to the interactions between
    polymer chains derived from hydrogen bonding. The “on-off” switchable release
    of PTX from the mesh was detected by the drug release test. Approximately 73%
    of loaded PTX was released from the mesh after eight cycles, whereas only a tiny
    amount of PTX was released during the cooling phase. Furthermore, hyperthermia
    combined with chemotherapy after exposure to an AMF showed significantly reduced
    cancer cell survival compared to the control group. Subsequent investigations
    have proven that a new injectable local hyperthermia chemotherapy platform could
    be developed for cancer treatment using this SNM.
  description_type: abstract
  lang: und

## Creator

- name: Lili Chen
  role: author
  organization: National Institute for Materials Science
- name: Nanami Fujisawa
  role: author
  orcid: https://orcid.org/0000-0002-8894-1790
  organization: National Institute for Materials Science
- name: Masato Takanohashi
  role: author
  organization: National Institute for Materials Science
- name: Mitsuhiro Ebara
  role: author
  orcid: https://orcid.org/0000-0002-7906-0350
  organization: National Institute for Materials Science

## Contact agent



## Publisher

organization: Frontiers Media SA

## Managing organization



## Keyword

- subject: nanofibers hydrogels cancer chemotherapy
  schema: not_defined

## Rights

- identifier: https://creativecommons.org/licenses/by/4.0/

## Other identifier(s)



## Data origin

- data_origin_type: other

## Embargo



## Journal

- title: Frontiers in Bioengineering and Biotechnology
  issn: '22964185'
  volume: '10'
  article_number: '1046147'

## Conference



## Related item



## Funding

- identifier: JP19H04476 JP20H05877
  funder_name: Japan Society for the Promotion of Science

## Instrument



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## Instrument managing organization



## Measurement method



## Specimen



## Chemical composition



## Structure for specimen



## Structural feature for specimen



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## Fileset

- id: 98103a90-2121-4f3d-95d1-9de9e9c29261
  filename: 22_BioengBiotech.pdf
  content_type: application/pdf
  size: 2327115
  md5: 17465a0054d3dcf9a7ed8887e88f9529

## Thumbnail

fileset_id: 98103a90-2121-4f3d-95d1-9de9e9c29261
filename: 22_BioengBiotech.pdf