# Graded or random – Effect of pore distribution in 3D titanium scaffolds on corrosion performance and response of hMSCs

https://mdr.nims.go.jp/datasets/8b0e4969-b39e-419b-9ab9-183e50d17be8

## File

- [BiomaterAdvances163(2024)213955.pdf](https://mdr.nims.go.jp/filesets/0dda455e-4be5-41c4-812b-8fa575d3963a/download) ([Detail](https://mdr.nims.go.jp/filesets/0dda455e-4be5-41c4-812b-8fa575d3963a.md))
- [BiomaterAdvances163(2024)213955_supplementary Figure1.pdf](https://mdr.nims.go.jp/filesets/dc2c511d-bc05-49c3-ad78-944aad4255d7/download) ([Detail](https://mdr.nims.go.jp/filesets/dc2c511d-bc05-49c3-ad78-944aad4255d7.md))

## Id

8b0e4969-b39e-419b-9ab9-183e50d17be8

## Local identifier



## Visibility

open_to_public

## State

published

## Created at

2024-07-12T08:05:56.601800Z

## Updated at

2024-07-16T03:30:19.371137Z

## Published at

2024-07-16T03:30:19.717969Z

## Doi



## First published url

https://doi.org/10.1016/j.bioadv.2024.213955

## Date published

2024-07-08

## Recorded date published

2024-10

## Resource type

journal_article

## Manuscript type

vor

## Collection



## Title

- title: Graded or random – Effect of pore distribution in 3D titanium scaffolds on
    corrosion performance and response of hMSCs
  title_type: original
  lang: en

## Description

- description: In this study, we investigated the effect of pore distribution on corrosion
    resistance and performance of human mesenchymal stem cells (hMSC) using titanium
    scaffolds fabricated by laser beam powder bed fusion. We designed two scaffold
    architectures with the same porosities (i.e., 75 %) but different distribution
    of pores of three sizes (200, 500, and 700 μm). The pores were either grouped
    in three zones (GRAD) or distributed randomly (RAND). Microfocus X-ray computed
    tomography revealed that the chemically polished GRAD and RAND scaffolds had the
    porosity of 69 ± 4 and 71 ± 4 %; the surface area of 1580 ± 101 and 991 ± 62 mm2;
    and the strut width of 221 ± 37 286 ± 14 μm, respectively. The apparent corrosion
    rate of chemically polished GRAD scaffold decreased with the immersion time extension,
    while that for polished RAND was increased. The RAND architecture outperformed
    the GRAD one with respect to hMSC proliferation (over two times higher although
    the GRAD scaffolds had 85 % higher initial cell retention) and migration from
    a monolayer. Our findings demonstrate that the pore distribution affects the biological
    properties of the titanium scaffolds for bone tissue engineering.
  description_type: abstract
  lang: und

## Creator

- name: J. Idaszek
  role: author
- name: B. Wysocki
  role: author
- name: E. Ura-Bińczyk
  role: author
- name: A. Dobkowska
  role: author
- name: W. Nowak
  role: author
- name: A. Yamamoto
  role: author
  orcid: https://orcid.org/0000-0002-9182-4886
  organization: National Institute for Materials Science
- name: G.D. Sulka
  role: author
- name: W. Święszkowski
  role: author

## Contact agent



## Publisher

organization: Elsevier BV

## Managing organization



## Keyword

- subject: Corrosion
  schema: not_defined
- subject: hMSC
  schema: not_defined
- subject: Pore distribution
  schema: not_defined
- subject: Titanium
  schema: not_defined
- subject: Laser beam powder bed fusion
  schema: not_defined

## Rights

- identifier: https://creativecommons.org/licenses/by/4.0/

## Other identifier(s)



## Data origin

- data_origin_type: other

## Embargo



## Journal

- title: Biomaterials Advances
  issn: '27729508'
  volume: '163'
  article_number: '213955'

## Conference



## Related item



## Funding

- identifier: 2017/25/B/ST8/01599
  funder_name: National Science Centre Poland

## Instrument



## Instrument operator



## Instrument managing organization



## Measurement method



## Specimen



## Chemical composition



## Structure for specimen



## Structural feature for specimen



## Specific property for specimen



## Process for specimen treatment



## Computational method



## Energy level/transition state



## Software



## Custom property



## Fileset

- id: 0dda455e-4be5-41c4-812b-8fa575d3963a
  filename: BiomaterAdvances163(2024)213955.pdf
  content_type: application/pdf
  size: 7214861
  md5: 60e5c1c28c38a74df686a5bb31b86391
- id: dc2c511d-bc05-49c3-ad78-944aad4255d7
  filename: BiomaterAdvances163(2024)213955_supplementary Figure1.pdf
  content_type: application/pdf
  size: 185355
  md5: 95ae3c135c4b2c96863ce5a77f2eb13b

## Thumbnail

fileset_id: 0dda455e-4be5-41c4-812b-8fa575d3963a
filename: BiomaterAdvances163(2024)213955.pdf