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In this study, we investigated the effect of pore distribution on corrosion resistance and performance of human mesenchymal stem cells (hMSC) using titanium scaffolds fabricated by laser beam powder bed fusion. We designed two scaffold architectures with the same porosities (i.e., 75 %) but different distribution of pores of three sizes (200, 500, and 700 μm). The pores were either grouped in three zones (GRAD) or distributed randomly (RAND). Microfocus X-ray computed tomography revealed that the chemically polished GRAD and RAND scaffolds had the porosity of 69 ± 4 and 71 ± 4 %; the surface area of 1580 ± 101 and 991 ± 62 mm2; and the strut width of 221 ± 37 286 ± 14 μm, respectively. The apparent corrosion rate of chemically polished GRAD scaffold decreased with the immersion time extension, while that for polished RAND was increased. The RAND architecture outperformed the GRAD one with respect to hMSC proliferation (over two times higher although the GRAD scaffolds had 85 % higher initial cell retention) and migration from a monolayer. Our findings demonstrate that the pore distribution affects the biological properties of the titanium scaffolds for bone tissue engineering.

Rights:

• Creative Commons BY Attribution 4.0 International
  

Keyword: Titanium, Laser beam powder bed fusion , Pore distribution , Corrosion, hMSC

Date published: 2024-07-08

Publisher: Elsevier BV

Journal:

• Biomaterials Advances (ISSN: 27729508) vol. 163 213955

Funding:

• National Science Centre Poland 2017/25/B/ST8/01599

Manuscript type: Publisher's version (Version of record)

MDR DOI:

First published URL: https://doi.org/10.1016/j.bioadv.2024.213955

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Updated at: 2024-07-16 12:30:19 +0900

Published on MDR: 2024-07-16 12:30:19 +0900