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In this study, we investigated the effect of pore distribution on corrosion resistance and performance of human mesenchymal stem cells (hMSC) using titanium scaffolds fabricated by laser beam powder bed fusion. We designed two scaffold architectures with the same porosities (i.e., 75 %) but different distribution of pores of three sizes (200, 500, and 700 μm). The pores were either grouped in three zones (GRAD) or distributed randomly (RAND). Microfocus X-ray computed tomography revealed that the chemically polished GRAD and RAND scaffolds had the porosity of 69 ± 4 and 71 ± 4 %; the surface area of 1580 ± 101 and 991 ± 62 mm2; and the strut width of 221 ± 37 286 ± 14 μm, respectively. The apparent corrosion rate of chemically polished GRAD scaffold decreased with the immersion time extension, while that for polished RAND was increased. The RAND architecture outperformed the GRAD one with respect to hMSC proliferation (over two times higher although the GRAD scaffolds had 85 % higher initial cell retention) and migration from a monolayer. Our findings demonstrate that the pore distribution affects the biological properties of the titanium scaffolds for bone tissue engineering.

権利情報:

• Creative Commons BY Attribution 4.0 International
  

キーワード: Titanium, Laser beam powder bed fusion , Pore distribution , Corrosion, hMSC

刊行年月日: 2024-07-08

出版者: Elsevier BV

掲載誌:

• Biomaterials Advances (ISSN: 27729508) vol. 163 213955

研究助成金:

• National Science Centre Poland 2017/25/B/ST8/01599

原稿種別: 出版者版 (Version of record)

MDR DOI:

公開URL: https://doi.org/10.1016/j.bioadv.2024.213955

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更新時刻: 2024-07-16 12:30:19 +0900

MDRでの公開時刻: 2024-07-16 12:30:19 +0900