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説明:

Precise spatial and temporal control of the fates of mesenchymal stromal cells (MSCs) through dynamic microenvironmental cues is essential for MSC-based tissue engineering. Artificial niches that recapitulate the spatiotemporal regulation of cell fates have been regarded as ideal platforms. Here, we engineered an artificial niche scaffold by integrating growth and chondrogenic induction factors that exerted staged effects on MSCs to direct different phases of cartilage regeneration. The scaffold was prepared by immobilizing heparin-binding epidermal growth factor-like growth factor and matrix metalloproteinase-2-cleavable peptide-tethered kartogenin-loaded liposomes within a gelatin/heparin/γ-PGA scaffold. The immobilized growth factor initially promoted MSC proliferation. The upregulation of proliferation-associated signaling served as an autonomous trigger for the subsequent release of kartogenin, thereby inducing MSC chondrogenesis.

権利情報:

• Creative Commons BY-NC Attribution-NonCommercial 4.0 International
  

キーワード: scaffold, artificial niche, cell fates, MMP-2, tissue engineering

刊行年月日: 2026-07-13

出版者: Royal Society of Chemistry (RSC)

掲載誌:

• Journal of Materials Chemistry B (ISSN: 2050750X) vol. 14 issue. 31 p. 9676-9687

研究助成金:

• Japan Society for the Promotion of Science 24K03289
• Support for Pioneering Research Initiated by the Next Generation JPMJSP2124

原稿種別: 出版者版 (Version of record)

MDR DOI:

公開URL: https://doi.org/10.1039/d6tb00939e

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更新時刻: 2026-10-19 09:42:12 +0900

MDRでの公開時刻: 2026-10-19 12:32:29 +0900