# In vitro analysis of insoluble salt formation mechanism associated with Mg corrosion—variations depending on the diffusion environment in model tissue

https://mdr.nims.go.jp/datasets/8967bfb2-ec2a-47de-afc9-b33071419f81

## Files

- [Biomed_Mater_19_025010.pdf](https://mdr.nims.go.jp/filesets/5f08959f-0c8e-4462-8902-f892180bc727/download) ([Detail](https://mdr.nims.go.jp/filesets/5f08959f-0c8e-4462-8902-f892180bc727.md))
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## Id

8967bfb2-ec2a-47de-afc9-b33071419f81

## Local identifier



## Visibility

open_to_public

## State

published

## Created at

2024-01-23T07:52:57.645078Z

## Updated at

2024-01-24T00:26:30.202798Z

## Published at

2024-01-24T03:30:13.691327Z

## Doi



## First published url

https://doi.org/10.1088/1748-605X/ad1d7f

## Date published

2024-03-01

## Recorded date published

2024-3-1

## Resource type

journal_article

## Manuscript type

vor

## Collection



## Title

- title: NA
  title_type: alternative
  lang: ja
- title: In vitro analysis of insoluble salt formation mechanism associated with Mg
    corrosion—variations depending on the diffusion environment in model tissue
  title_type: original
  lang: en

## Description

- description: "Magnesium (Mg) alloys have attracted attention as biodegradable metals,
    but the details of their\r\ncorrosion behavior under biological environment have
    not been elucidated. Previous studies have\r\nsuggested that diffusion through
    blood flow may influence Mg corrosion. Therefore, to understand\r\nthe degradation
    behaviors of Mg, we analyzed insoluble salt precipitation associated with Mg\r\ncorrosion
    in model tissue with different diffusion rates. A pure Mg specimen was immersed
    into a\r\nmodel tissue prepared with cell culture medium supplemented by a thickener
    at a different\r\nconcentration (0.2%–0.5%) to form the gel. Micro-focus x-ray
    computed tomography of the gel\r\nwas performed to observe gas cavity formation
    around the specimen. The insoluble salt layer\r\nformed on the specimen surface
    were analyzed by scanning electron microscopy with\r\nenergy-dispersive x-ray
    spectroscopy, and Raman spectroscopy. As results, gas cavity formation\r\nwas
    observed for all specimens. At day 7, the gas cavity volume was the highest at
    0.5% thickener\r\ngel followed by 0.3% thickener gel. The insoluble salts were
    classified into three types based on\r\ntheir morphology; plate-like, granular-like,
    and crater-like salts. The crater-like salts were observed\r\nto cover 16.8 ±
    3.9% of the specimen surface immersed in the 0.5% thickener gel, at the specimen\r\narea
    contacted to the gas cavity. The crater-like salts were composed by Mg hydroxide
    and\r\ncarbonate from the deepest to the top layer. In plate-like or granular-like
    salts, Mg carbonate was\r\nformed in the deepest layer, but phosphates and carbonates,
    mainly containing calcium not Mg,\r\nwere formed on the surface layer. In conclusion,
    the increase in the thickener concentration\r\nincreased the gas cavity volume
    contacting to the specimen surface, resulting in the increase in\r\nprecipitation
    of Mg hydroxide and carbonate, composing crater-like salts. Mg hydroxide and\r\ncarbonate
    precipitation suggests the local increase in OH− concentration, which may be attributed\r\nto
    the decrease in diffusion rate."
  description_type: abstract
  lang: eng

## Creator

- name: Masanobu Hayashi
  role: author
  orcid: https://orcid.org/0009-0009-0501-3234
- name: Akiko Yamamoto
  role: author
- name: Takayuki Aizawa
  role: author
  orcid: https://orcid.org/0000-0002-6231-0368
- name: Yu Yusa
  role: author
- name: Yoshinaka Shimizu
  role: author
- name: Yoshimichi Imai
  role: author
  orcid: https://orcid.org/0000-0001-5360-958X

## Contact agent



## Publisher

organization: IOP Publishing

## Managing organization



## Keyword

- subject: magnesium
  schema: not_defined
- subject: in vitro model tissue
  schema: not_defined
- subject: corrosion
  schema: not_defined
- subject: insoluble salt precipitation
  schema: not_defined
- subject: Raman spectroscopy
  schema: not_defined

## Rights

- description: Any further distribution of this work must maintain attribution to
    the author(s) and the title of the work, journal citation and DOI.
  identifier: https://creativecommons.org/licenses/by/4.0/

## Other identifier(s)



## Data origin



## Embargo



## Journal

- title: Biomedical Materials
  issn: 1748605X
  volume: '19'
  issue: '2'
  start_page: 1
  end_page: 13

## Conference



## Related item



## Funding



## Instrument



## Instrument operator



## Instrument managing organization



## Measurement method



## Specimen



## Chemical composition



## Structure for specimen



## Structural feature for specimen



## Specific property for specimen



## Process for specimen treatment



## Computational method



## Energy level/transition state



## Software



## Custom property



## Fileset

- id: 5f08959f-0c8e-4462-8902-f892180bc727
  filename: Biomed_Mater_19_025010.pdf
  content_type: application/pdf
  size: 6081066
  md5: c374ff0406c2428948609ab4c8303224
- id: 9f7d24da-a174-42ac-a55b-0d508866fef3
  filename: Biomed_Mater_19_025010_supplemental_materials.pdf
  content_type: application/pdf
  size: 61575
  md5: ec176ce518e19bba551e0bb978b95de5

## Thumbnail

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filename: Biomed_Mater_19_025010.pdf