# Cell-delivering injectable hydrogels with tunable microporous structures improve therapeutic efficacy for volumetric muscle loss

https://mdr.nims.go.jp/datasets/890e0a53-1476-4cd9-859b-a527e3bc30e3

## Files

- [67. Adv Funct Materials - 2025 - Yasue - Cell‐Delivering Injectable Hydrogels with Tunable Microporous Structures Improve.pdf](https://mdr.nims.go.jp/filesets/45bc96d8-576f-4da9-b851-cba4f19c41de/download) ([Detail](https://mdr.nims.go.jp/filesets/45bc96d8-576f-4da9-b851-cba4f19c41de.md))

## Id

890e0a53-1476-4cd9-859b-a527e3bc30e3

## Local identifier



## Visibility

open_to_public

## State

published

## Created at

2025-06-27T00:59:25.677100Z

## Updated at

2025-06-27T08:03:30.088786Z

## Published at

2025-06-27T07:19:09.809153Z

## Doi



## First published url

https://doi.org/10.1002/adfm.202508278

## Date published

2025-06-25

## Recorded date published

2025-11

## Resource type

journal_article

## Manuscript type

vor

## Collection



## Title

- title: Cell-delivering injectable hydrogels with tunable microporous structures
    improve therapeutic efficacy for volumetric muscle loss
  title_type: original
  lang: en

## Description

- description: Volumetric muscle loss (VML) is a traumatic or surgical injury to the
    skeletal muscles that causes irrecoverable functional loss leading to chronic
    deficits and long-term disability. Although cell transplantation is a potent therapeutic
    approach, treating VML remains challenging because of the poor graft survival
    of cell suspensions injected into defects. Here, we report the development of
    tunable micropore-forming injectable hydrogels to deliver mesenchymal stem cells
    (MSCs) for VML treatment. The molecular modification of gelatin with hydrogen-bonding
    functional groups induces liquid-liquid phase separation when mixed with chemically
    crosslinkable gelatin to form injectable hydrogels with tunable microporous structures.
    MSCs encapsulated in porous hydrogels show higher cell adhesion, spreading, proliferation,
    and secretion of paracrine signals than those encapsulated in non-porous hydrogels.
    Porous hydrogels enhance cell infiltration and myoblast differentiation Additionally,
    porous hydrogels improve the graft survival of transplanted MSCs in VML mouse
    models and ameliorate therapeutic efficiency. This controlled microstructure-containing
    injectable hydrogel may serve as a cell-delivering scaffold to improve the efficacy
    of cell transplantation therapies in regenerative medicine.
  description_type: abstract
  lang: eng

## Creator

- name: Hana Yasue
  role: author
  organization: National Institute for Materials Science
  department: Research Center for Macromolecules and Biomaterials/Biomaterials Field/Polymeric
    Biomaterials Group
- name: Tetsushi Taguchi
  role: author
  orcid: https://orcid.org/0000-0003-2541-2530
  organization: National Institute for Materials Science
  department: Research Center for Macromolecules and Biomaterials/Biomaterials Field/Polymeric
    Biomaterials Group
- name: Taka-Aki Asoh
  role: author
  organization: Tokyo University of Science
- name: Akihiro Nishiguchi
  role: author
  orcid: https://orcid.org/0000-0002-3160-6385
  organization: National Institute for Materials Science
  department: Research Center for Macromolecules and Biomaterials/Biomaterials Field/Polymeric
    Biomaterials Group

## Contact agent



## Publisher

organization: Advanced Functional Materials

## Managing organization



## Keyword

- subject: Regenerative medicine
  schema: not_defined
- subject: Hydrogel
  schema: not_defined
- subject: Liquid-liquid phase separation
  schema: not_defined
- subject: Porous material
  schema: not_defined
- subject: Mechanobiology
  schema: not_defined

## Rights

- identifier: https://creativecommons.org/licenses/by-nc-nd/4.0/

## Other identifier(s)



## Data origin

- data_origin_type: other

## Embargo



## Journal

- title: ADVANCED FUNCTIONAL MATERIALS
  issn: '16163028'

## Conference



## Related item



## Funding



## Instrument



## Instrument operator



## Instrument managing organization



## Measurement method



## Specimen



## Chemical composition



## Structure for specimen



## Structural feature for specimen



## Specific property for specimen



## Process for specimen treatment



## Computational method



## Energy level/transition state



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## Custom property



## Fileset

- id: 45bc96d8-576f-4da9-b851-cba4f19c41de
  filename: 67. Adv Funct Materials - 2025 - Yasue - Cell‐Delivering Injectable Hydrogels
    with Tunable Microporous Structures Improve.pdf
  content_type: application/pdf
  size: 5741417
  md5: 1afa0c388fabb8b2d7e14468ebc432ba

## Thumbnail

fileset_id: 45bc96d8-576f-4da9-b851-cba4f19c41de
filename: 67. Adv Funct Materials - 2025 - Yasue - Cell‐Delivering Injectable Hydrogels
  with Tunable Microporous Structures Improve.pdf