# Statistical Evaluation of Total Expiratory Breath Samples Collected throughout a Year: Reproducibility and Applicability toward Olfactory Sensor-Based Breath Diagnostics

https://mdr.nims.go.jp/datasets/882ef4bf-a577-454f-9eea-f0858de5189c

## File

- [sensors-21-04742.pdf](https://mdr.nims.go.jp/filesets/d97b8d51-51fc-44bd-ab8b-2d93457cbf71/download) ([Detail](https://mdr.nims.go.jp/filesets/d97b8d51-51fc-44bd-ab8b-2d93457cbf71.md))

## Id

882ef4bf-a577-454f-9eea-f0858de5189c

## Local identifier



## Visibility

open_to_public

## State

published

## Created at

2023-07-21T05:36:36.289315Z

## Updated at

2024-01-05T13:12:40.317420Z

## Published at

2023-07-25T04:55:20.540422Z

## Doi



## First published url

https://doi.org/10.3390/s21144742

## Date published

2021-07-11

## Recorded date published



## Resource type

journal_article

## Manuscript type

vor

## Collection



## Title

- title: 'Statistical Evaluation of Total Expiratory Breath Samples Collected throughout
    a Year: Reproducibility and Applicability toward Olfactory Sensor-Based Breath
    Diagnostics'
  title_type: original
  lang: en

## Description

- description: The endogenous volatile organic compounds (VOCs) in exhaled breath
    can be promising biomarkers for various diseases including cancers. An olfactory
    sensor has a possibility for extracting a specific feature from collective variations
    of the related VOCs with a certain health condition. For this approach, it is
    important to establish a feasible protocol for sampling exhaled breath in practical
    conditions to provide reproducible signal features. Here we report a robust protocol
    for the breath analysis, focusing on total expiratory breath measured by a Membrane-type
    Surface stress Sensor (MSS), which possesses practical characteristics for artificial
    olfactory systems. To assess its reproducibility, 83 exhaled breath samples were
    collected from one subject throughout more than a year. It has been confirmed
    that the reduction of humidity effects on the sensing signals either by controlling
    the humidity of purging room air or by normalizing the signal intensities leads
    to reasonable reproducibility verified by statistical analyses. We have also demonstrated
    the applicability of the protocol for detecting a target material by discriminating
    exhaled breaths collected from different subjects with pre- and post-alcohol ingestion
    on different occasions. This simple yet reproducible protocol based on the total
    expiratory breath measured by the MSS olfactory sensors will contribute to exploring
    the possibilities of clinical applications of breath diagnostics.
  description_type: abstract
  lang: eng

## Creator

- name: Katsushige Inada
  role: author
- name: Hiroshi Kojima
  role: author
- name: Yukiko Cho-Isoda
  role: author
- name: Ryo Tamura
  role: author
  orcid: https://orcid.org/0000-0002-0349-358X
  organization: National Institute for Materials Science
  ror: https://ror.org/026v1ze26
- name: Gaku Imamura
  role: author
  orcid: https://orcid.org/0000-0002-3130-7190
  organization: National Institute for Materials Science
  ror: https://ror.org/026v1ze26
- name: Kosuke Minami
  role: author
  orcid: https://orcid.org/0000-0003-4145-1118
  organization: National Institute for Materials Science
  ror: https://ror.org/026v1ze26
- name: Takahiro Nemoto
  role: author
  organization: National Institute for Materials Science
  ror: https://ror.org/026v1ze26
- name: Genki Yoshikawa
  role: author
  orcid: https://orcid.org/0000-0002-9136-8964
  organization: National Institute for Materials Science
  ror: https://ror.org/026v1ze26

## Contact agent



## Publisher

organization: MDPI AG

## Managing organization



## Keyword

- subject: nanomechanical sensors
  schema: not_defined
- subject: breath analysis
  schema: not_defined

## Rights

- identifier: https://creativecommons.org/licenses/by/4.0/

## Other identifier(s)



## Data origin



## Embargo



## Journal

- title: SENSORS
  issn: '14248220'
  volume: '21'
  issue: '14'
  start_page: 4742
  end_page: 4742

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## Measurement method



## Specimen



## Chemical composition



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## Fileset

- id: d97b8d51-51fc-44bd-ab8b-2d93457cbf71
  filename: sensors-21-04742.pdf
  content_type: application/pdf
  size: 3955308
  md5: ccbed1a05997c3089e6a472281337223

## Thumbnail

fileset_id: d97b8d51-51fc-44bd-ab8b-2d93457cbf71
filename: sensors-21-04742.pdf