# Development of Drug-loaded Shape-Memory Polymer Urethral Stent (SMPUS) for treatment of Prostatic Urethral Obstruction (PUO)

https://mdr.nims.go.jp/datasets/87b4823c-2d5b-49a2-8d33-f076be7864ef

## File

- [development-of-a-drug-loaded-shape-memory-polymer-urethral-stent-(smpus)-for-treatment-of-prostatic-urethral.pdf](https://mdr.nims.go.jp/filesets/66961a9e-d499-4907-a1cc-f50ad770934a/download) ([Detail](https://mdr.nims.go.jp/filesets/66961a9e-d499-4907-a1cc-f50ad770934a.md))

## Id

87b4823c-2d5b-49a2-8d33-f076be7864ef

## Local identifier



## Visibility

open_to_public

## State

published

## Created at

2025-12-10T02:15:05.114979Z

## Updated at

2025-12-10T07:30:19.659207Z

## Published at

2025-12-10T07:25:16.821103Z

## Doi



## First published url

https://doi.org/10.1021/acsomega.5c05903

## Date published

2025-08-19

## Recorded date published

2025-8-19

## Resource type

journal_article

## Manuscript type

vor

## Collection



## Title

- title: Development of Drug-loaded Shape-Memory Polymer Urethral Stent (SMPUS) for
    treatment of Prostatic Urethral Obstruction (PUO)
  title_type: original
  lang: en

## Description

- description: Prostatic Urethral Obstruction (PUO) is the urethral narrowing by the
    external pressure of an enlarged prostate, which hinders the ability to pass urine
    normally. The most common reasons for the enlarged prostate are prostate cancer
    and benign prostatic hyperplasia (BPH). In this study, we aimed to develop a drug-loaded
    shape-memory polymer urethral stent (SMPUS) to address the PUO. The SMPUS was
    designed to combine both mechanical and chemical/herbal treatment of PUO. Successfully,
    SMPUS shows a potential mechanical efficacy through its shape-memory properties
    that ensure the patency of the urethral lumen by restoring its tube-like stent
    shape by flushing with hot water at its melting temperature (Tm). Additionally,
    the in-vitro drug release investigation shows the capability of SMPUS to serve
    as a versatile drug delivery platform, after further in-vivo investigation, enabling
    the release of the selected drugs to treat the primary diseases associated with
    PUO while mitigating the systemic side effects associated with conventional treatments.
    Both polymer and drug concentrations can be modulated to achieve the required
    mechanical and thermal properties based on the case progress. This adaptability
    of the developed SMPUS allows for future in-vivo and clinical trials in medical
    applications.
  description_type: abstract
  lang: eng

## Creator

- name: Alaa Fehaid
  role: author
  orcid: https://orcid.org/0000-0001-7759-663X
  organization: National Institute for Materials Science
  department: Research Center for Macromolecules and Biomaterials/Biomaterials Field/Smart
    Polymers Group
- name: Koichiro Uto
  role: author
  orcid: https://orcid.org/0000-0001-7091-0585
  organization: National Institute for Materials Science
  department: Research Center for Macromolecules and Biomaterials/Biomaterials Field/Smart
    Polymers Group
- name: Toshimasa Homma
  role: author
  organization: National Institute for Materials Science
  department: Research Center for Macromolecules and Biomaterials/Biomaterials Field/Smart
    Polymers Group
- name: Ailifeire Fulati
  role: author
  orcid: https://orcid.org/0000-0002-0356-3381
  organization: National Institute for Materials Science
  department: Research Center for Macromolecules and Biomaterials/Macromolecules Field/Data-driven
    Polymer Design Group
- name: Maëlys Tisserant
  role: author
- name: Jun Nakanishi
  role: author
  orcid: https://orcid.org/0000-0003-4457-6581
  organization: National Institute for Materials Science
  department: Research Center for Macromolecules and Biomaterials/Biomaterials Field/Mechanobiology
    Group
- name: Mitsuhiro Ebara
  role: author
  orcid: https://orcid.org/0000-0002-7906-0350
  organization: National Institute for Materials Science
  department: Research Center for Macromolecules and Biomaterials/Biomaterials Field

## Contact agent



## Publisher

organization: ACS

## Managing organization



## Keyword

- subject: Shape-memory polymer
  schema: not_defined
- subject: Prostate
  schema: not_defined
- subject: Drug
  schema: not_defined

## Rights

- identifier: https://creativecommons.org/licenses/by/4.0/

## Other identifier(s)



## Data origin

- data_origin_type: other

## Embargo



## Journal

- title: ACS OMEGA
  issn: '24701343'
  volume: '10'
  issue: '32'
  start_page: 36672
  end_page: 36681

## Conference



## Related item



## Funding

- identifier: 24KF0165
  funder_name: JSPS

## Instrument



## Instrument operator



## Instrument managing organization



## Measurement method



## Specimen



## Chemical composition



## Structure for specimen



## Structural feature for specimen



## Specific property for specimen



## Process for specimen treatment



## Computational method



## Energy level/transition state



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## Fileset

- id: 66961a9e-d499-4907-a1cc-f50ad770934a
  filename: development-of-a-drug-loaded-shape-memory-polymer-urethral-stent-(smpus)-for-treatment-of-prostatic-urethral.pdf
  content_type: application/pdf
  size: 9726578
  md5: 1c11c322ccb85b654176e52c0d7939c1

## Thumbnail

fileset_id: 66961a9e-d499-4907-a1cc-f50ad770934a
filename: development-of-a-drug-loaded-shape-memory-polymer-urethral-stent-(smpus)-for-treatment-of-prostatic-urethral.pdf