論文 Multidisciplinary approaches for enzyme biocatalysis in pharmaceuticals: protein engineering, computational biology, and nanoarchitectonics

Suhyeon Kim ORCID ; Seongmin Ga ORCID ; Hayeon Bae ORCID ; Ronald Sluyter ORCID ; Konstantin Konstantinov ORCID ; Lok Kumar Shrestha SAMURAI ORCID (National Institute for Materials Science) ; Yong Ho Kim ORCID ; Jung Ho Kim ORCID ; Katsuhiko Ariga SAMURAI ORCID (National Institute for Materials Science)

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引用
Suhyeon Kim, Seongmin Ga, Hayeon Bae, Ronald Sluyter, Konstantin Konstantinov, Lok Kumar Shrestha, Yong Ho Kim, Jung Ho Kim, Katsuhiko Ariga. Multidisciplinary approaches for enzyme biocatalysis in pharmaceuticals: protein engineering, computational biology, and nanoarchitectonics. EES Catalysis. 2023, 2 (1), 14-48. https://doi.org/10.1039/d3ey00239j
SAMURAI

説明:

(abstract)

Enzyme biocatalysis is reshaping pharmaceutical synthesis, offering sustainable and efficient pathways for drug discovery and production. This paradigm shift towards eco-friendly methodologies addresses concerns inherent in traditional chemical synthesis. Enzymes, celebrated for their precision and adaptability to mild conditions, are poised as ideal candidates for pharmaceutical applications. Their versatility facilitates the synthesis of diverse pharmaceutical compounds, ensuring precise drug design and minimizing environmental impact. The integration of multidisciplinary approaches, including protein engineering, computational biology, and nanoarchitectonics, holds the potential to propel enzyme biocatalysis even further. Protein engineering utilizes directed evolution and rational design to customize enzymes, enhancing their stability and efficacy.

権利情報:

キーワード: enzyme, biocatalysis, protein

刊行年月日: 2023-10-28

出版者: Royal Society of Chemistry (RSC)

掲載誌:

  • EES Catalysis (ISSN: 2753801X) vol. 2 issue. 1 p. 14-48

研究助成金:

  • National Research Foundation of Korea 023R1A2C3005731
  • National Research Foundation of Korea 2021R1A4A1033424

原稿種別: 出版者版 (Version of record)

MDR DOI:

公開URL: https://doi.org/10.1039/d3ey00239j

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更新時刻: 2024-01-18 16:57:46 +0900

MDRでの公開時刻: 2024-01-19 08:30:14 +0900

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