# Tailoring cell behaviour by surface micropatterning and interconnected porous structure of gelatin/nano-silica/PLGA 3D composite scaffold for bone tissue engineering

https://mdr.nims.go.jp/datasets/839ff0f8-b0db-4502-a3c3-4c90c4f3090e

## File

- [Putri-2025-Tailoring cell behaviour by surface.pdf](https://mdr.nims.go.jp/filesets/905db751-a824-4682-92c7-2fd2c9d50322/download) ([Detail](https://mdr.nims.go.jp/filesets/905db751-a824-4682-92c7-2fd2c9d50322.md))

## Id

839ff0f8-b0db-4502-a3c3-4c90c4f3090e

## Local identifier



## Visibility

open_to_public

## State

published

## Created at

2025-09-09T01:05:19.814645Z

## Updated at

2025-09-09T07:30:23.205221Z

## Published at

2025-09-09T07:18:45.455032Z

## Doi



## First published url

https://doi.org/10.1039/d5ra02891d

## Date published

2025-08-12

## Recorded date published

2025-8-11

## Resource type

journal_article

## Manuscript type

vor

## Collection



## Title

- title: Tailoring cell behaviour by surface micropatterning and interconnected porous
    structure of gelatin/nano-silica/PLGA 3D composite scaffold for bone tissue engineering
  title_type: original
  lang: en

## Description

- description: In this work, a controllable interconnected three-dimensional (3D)
    porous scaffold with surface micropatterning was fabricated. Nozzle-based Aerojet
    dispenser 3D printing was used to form printed ice as a fugitive ink combined
    with a freeze-drying method of gelatin/nano-silica/poly lactic-co-glycolic acid
    (PLGA) and ice particulates to fabricate a composite scaffold with supporting
    properties. Several designs of printed ice were explored and the HUVECs' behavior
    on different surface patterns was analyzed. The results showed that HUVECs exhibited
    orientation adhesion and growth with a certain direction after 6 days of culture.
    The 3D-controlled interconnected porous scaffolds with surface micropatterning
    then were used for the 3D culture of hMSCs. The hMSCs analysis showed a facilitating
    effect for cell distribution and growth in the 3D composite scaffolds compared
    to the control scaffold without interconnected porous structure and surface micropatterning.
  description_type: abstract
  lang: und

## Creator

- name: Nur Rofiqoh Eviana Putri
  role: author
  orcid: https://orcid.org/0000-0002-4492-4956
- name: Huajian Chen
  role: author
- name: Naoki Kawazoe
  role: author
  orcid: https://orcid.org/0000-0003-3916-0709
- name: Felicity R. A. J. Rose
  role: author
  orcid: https://orcid.org/0000-0001-6640-8840
- name: Ricky D. Wildman
  role: author
- name: Guoping Chen
  role: author
  orcid: https://orcid.org/0000-0001-6753-3678

## Contact agent



## Publisher

organization: Royal Society of Chemistry (RSC)

## Managing organization



## Keyword

- subject: surface micropatterning
  schema: not_defined
- subject: interconnected porous structure
  schema: not_defined
- subject: gelatin
  schema: not_defined
- subject: nano-silica
  schema: not_defined
- subject: PLGA
  schema: not_defined
- subject: scaffold
  schema: not_defined
- subject: bone tissue engineering
  schema: not_defined

## Rights

- identifier: cc-by-nc-3.0

## Other identifier(s)



## Data origin

- data_origin_type: other

## Embargo



## Journal

- title: RSC Advances
  issn: '20462069'
  volume: '15'
  issue: '35'
  start_page: 28581
  end_page: 28591

## Conference



## Related item



## Funding

- identifier: 24K03289
  funder_name: Japan Society for the Promotion of Science

## Instrument



## Instrument operator



## Instrument managing organization



## Measurement method



## Specimen



## Chemical composition



## Structure for specimen



## Structural feature for specimen



## Specific property for specimen



## Process for specimen treatment



## Computational method



## Energy level/transition state



## Software



## Custom property



## Fileset

- id: 905db751-a824-4682-92c7-2fd2c9d50322
  filename: Putri-2025-Tailoring cell behaviour by surface.pdf
  content_type: application/pdf
  size: 3139134
  md5: dcaa7d868605ad4611757a4a1d5b1490

## Thumbnail

fileset_id: 905db751-a824-4682-92c7-2fd2c9d50322
filename: Putri-2025-Tailoring cell behaviour by surface.pdf