# Observation of odd–even effect in 1-alcohols through pentapeptide-coated quartz crystal microbalance sensors with molecular docking study

https://mdr.nims.go.jp/datasets/81d3adce-39f2-45c3-9123-322db8a7588b

## File

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## Id

81d3adce-39f2-45c3-9123-322db8a7588b

## Local identifier



## Visibility

open_to_public

## State

published

## Created at

2025-06-30T01:36:56.259737Z

## Updated at

2025-11-13T07:30:16.010935Z

## Published at

2025-11-13T07:24:27.221452Z

## Doi

https://doi.org/10.48505/nims.5905

## First published url

https://doi.org/10.1063/5.0254577

## Date published

2025-04-21

## Recorded date published

2025-4-21

## Resource type

journal_article

## Manuscript type

accepted_manuscript

## Collection



## Title

- title: Observation of odd–even effect in 1-alcohols through pentapeptide-coated
    quartz crystal microbalance sensors with molecular docking study
  title_type: original
  lang: en

## Description

- description: The discrimination between odd and even carbon chain molecules is crucial
    in detecting odd chain metabolites resulting from impaired biosynthetic processes.
    However, the discrimination of these metabolomes via gas sensors presents significant
    challenges due to the lack of connection between material-gas interaction and
    odd-even carbon chain molecules. In this study, a homologous series of 1-alcohols
    is systematically investigated, quantitatively comparing the measured signals
    obtained using pentapeptide-coated gas sensors and pentapeptide-gas interactions
    calculated via molecular docking simulations. The pentapeptide-coated gas sensor
    exhibits a clear odd-even effect in both absorption and desorption processes,
    demonstrating better discrimination between odd- and even-numbered carbon compounds.
    The results indicate that the odd-even effect during the absorption process is
    closely associated with the hydrophobic interaction between a pentapeptide and
    a gas molecule, while the interactions affecting the desorption phase may vary
    depending on the pentapeptide properties. The insights into the molecular interactions
    involved in the odd-even effect will facilitate the development of materials for
    detecting odd-chain metabolites, which can enhance the accuracy of gas-sensing
    technologies toward health monitoring applications.
  description_type: abstract
  lang: eng

## Creator

- name: Thuc Anh Ngo
  role: author
  department: Research Center for Macromolecules and Biomaterials/Biomaterials Field/Olfactory
    Sensors Group
- name: Kosuke Minami
  role: author
  orcid: https://orcid.org/0000-0003-4145-1118
  organization: National Institute for Materials Science
  department: Research Center for Macromolecules and Biomaterials/Biomaterials Field/Olfactory
    Sensors Group
- name: Tanju Yildirim
  role: author
  orcid: https://orcid.org/0000-0002-0269-4718
  organization: National Institute for Materials Science
  department: Research Center for Macromolecules and Biomaterials/Biomaterials Field/Olfactory
    Sensors Group
- name: Kota Shiba
  role: author
  orcid: https://orcid.org/0000-0001-7775-0318
  organization: National Institute for Materials Science
  department: Research Center for Macromolecules and Biomaterials/Biomaterials Field/Olfactory
    Sensors Group
- name: Genki Yoshikawa
  role: author
  orcid: https://orcid.org/0000-0002-9136-8964
  organization: National Institute for Materials Science
  department: Research Center for Macromolecules and Biomaterials/Biomaterials Field/Olfactory
    Sensors Group

## Contact agent



## Publisher

organization: AIP Publishing

## Managing organization



## Keyword

- subject: odd-even effects
  schema: not_defined
- subject: gas sensor
  schema: not_defined
- subject: volatile organic compounds
  schema: not_defined

## Rights

- description: 'This article may be downloaded for personal use only. Any other use
    requires prior permission of the author and AIP Publishing. This article appeared
    in Thuc Anh Ngo, Kosuke Minami, Tanju Yildirim, Kota Shiba, Genki Yoshikawa; Observation
    of odd–even effect in 1-alcohols through pentapeptide-coated quartz crystal microbalance
    sensors with molecular docking study. Appl. Phys. Lett. 21 April 2025; 126 (16):
    163701 and may be found at https://doi.org/10.1063/5.0254577.'
  identifier: http://rightsstatements.org/vocab/InC/1.0/

## Other identifier(s)



## Data origin

- data_origin_type: other

## Embargo



## Journal

- title: Applied Physics Letters
  issn: '00036951'
  volume: '126'
  issue: '16'
  article_number: '163701'

## Conference



## Related item



## Funding

- funder_name: Public/Private R&D Investment Strategic Expansion Program

## Instrument



## Instrument operator



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## Measurement method



## Specimen



## Chemical composition



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## Thumbnail

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filename: Manuscript_TAN_GY.docx