# Poly(L-lysine)-block-poly(ethylene glycol)-block-poly(L-lysine) triblock copolymers for the preparation of flower micelles and their irreversible hydrogel formation

https://mdr.nims.go.jp/datasets/7b338251-e816-4868-a924-af693d12562c

## File

- [Poly L-lysine -block-poly ethylene glycol -block-poly L-lysine  triblock copolymers for the preparation of flower micelles and their irreversible hydr.pdf](https://mdr.nims.go.jp/filesets/389c3816-194f-49cf-a958-625237284902/download) ([Detail](https://mdr.nims.go.jp/filesets/389c3816-194f-49cf-a958-625237284902.md))

## Id

7b338251-e816-4868-a924-af693d12562c

## Local identifier



## Visibility

open_to_public

## State

published

## Created at

2024-12-11T06:13:35.286649Z

## Updated at

2025-07-16T07:17:03.303735Z

## Published at

2024-12-12T07:30:32.715120Z

## Doi

https://doi.org/10.48505/nims.5142

## First published url

https://doi.org/10.1080/14686996.2024.2432856

## Date published

2025-12-31

## Recorded date published

2025-12-31

## Resource type

journal_article

## Manuscript type

accepted_manuscript

## Collection



## Title

- title: Poly(L-lysine)-block-poly(ethylene glycol)-block-poly(L-lysine) triblock
    copolymers for the preparation of flower micelles and their irreversible hydrogel
    formation
  title_type: original
  lang: en

## Description

- description: Poly(L-lysine)-block-poly(ethylene glycol)-block-poly(L-lysine) (PLys-block-PEG-block-PLys)
    triblock copolymers formed polyion complex (PIC) with poly(acrylic acid) (PAAc)
    or sodium poly(styrenesulfonate) (PSS), leading to the formation of flower micelle-type
    nanoparticles (NanoLys/PAAc or NanoLys/PSS) with tens of nanometers size in water
    at a polymer concentration of 10 mg/mL. The flower micelles exhibited irreversible
    temperature-driven sol-gel transitions at physiological ionic strength, even at
    low polymer concentrations such as 40 mg/mL, making them promising candidates
    for injectable hydrogel applications. Rheological studies showed that the chain
    length of PLys segments and the choice of polyanions significantly impacted irreversible
    hydrogel formation, with PSS being superior to PAAc for the formation. The incorporation
    of silica gel nanoparticles into the PIC flower micelles also resulted in irreversible
    gelation phenomena. The highest storage modulus exceeded 10 kPa after gelation,
    which is sufficient for practical applications. This study demonstrates the potential
    of these PIC-based hydrogels as biomaterials with tunable properties for biomedical
    applications.
  description_type: abstract
  lang: en

## Creator

- name: Yuta Koda
  role: author
  organization: University of Tsukuba
  department: a Institute of Materials Science, Faculty of Pure and Applied Sciences
- name: Yukio Nagasaki
  role: author
  organization: University of Tsukuba
  department: a Institute of Materials Science, Faculty of Pure and Applied Sciences,

## Contact agent



## Publisher

organization: Taylor & Francis

## Managing organization



## Keyword

- subject: Injectable hydrogels
  schema: not_defined
- subject: polyion complex
  schema: not_defined
- subject: sol-gel transition
  schema: not_defined
- subject: poly(L-lysine)-block-PEG-block-poly(L-lysine) triblock copolymers
  schema: not_defined
- subject: silica gel nanoparticles
  schema: not_defined
- subject: modulus
  schema: not_defined

## Rights

- identifier: https://creativecommons.org/licenses/by/4.0/

## Other identifier(s)



## Data origin

- data_origin_type: other

## Embargo



## Journal

- title: Science and Technology of Advanced Materials
  issn: '14686996'
  volume: Vol.25
  article_number: '2432856'

## Conference



## Related item



## Funding



## Instrument



## Instrument operator



## Instrument managing organization



## Measurement method



## Specimen



## Chemical composition



## Structure for specimen



## Structural feature for specimen



## Specific property for specimen



## Process for specimen treatment



## Computational method



## Energy level/transition state



## Software



## Custom property



## Fileset

- id: 389c3816-194f-49cf-a958-625237284902
  filename: Poly L-lysine -block-poly ethylene glycol -block-poly L-lysine  triblock
    copolymers for the preparation of flower micelles and their irreversible hydr.pdf
  content_type: application/pdf
  size: 6001146
  md5: c3ae3faa342d2051d73f5499f5e0bcaa

## Thumbnail

fileset_id: 389c3816-194f-49cf-a958-625237284902
filename: Poly L-lysine -block-poly ethylene glycol -block-poly L-lysine  triblock
  copolymers for the preparation of flower micelles and their irreversible hydr.pdf